The coagulation system changes in patients with chronic heart failure
| Autor: | Lolita Kursvietiene, Artūras Kašauskas, Ausra Mongirdiene |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Blood Platelets
medicine.medical_specialty endothelium 616.12-008.46 [udc] Emotions Fibrinogen Von Willebrand factor Internal medicine medicine Humans Platelet Platelet activation chronic heart failure coagulation system fibrinogen platelets Blood Coagulation Heart Failure biology business.industry Heart failure Chronic disease Blood coagulation Blood platelets Endothelium vascular General Medicine medicine.disease Angiotensin II Blood Coagulation Factors Coagulation Chronic Disease Cardiology biology.protein business Platelet factor 4 medicine.drug |
| Zdroj: | Medicina; Volume 46; Issue 9; Pages: 642 Medicina, Kaunas : Lietuvos sveikatos mokslų universitetas, 2010, t. 46, Nr. 9, p. 642-647 Medicina Volume 46 Issue 9 |
| ISSN: | 1648-9144 1010-660X |
| DOI: | 10.3390/medicina46090091 |
| Popis: | Though heart failure can mainly be caused by systolic or diastolic dysfunction, the impairments of the neurohormonal, immune, and hemostatic systems are observed too. Therefore, it is not easy to determine etiology of the syndrome. Parameters that can be helpful to predict chronic heart failure, to evaluate its course and the risk of complications are still being searched. The aim of this article is to review the recent studies in order to find the links between the coagulation system and the development of chronic heart failure. Stress is a key factor for the development of most diseases including chronic heart failure too. Signals of emotional and physical stress via particular structures trigger an increase in concentrations of the following hormones: noradrenaline, renin, angiotensin II, aldosterone, vasopressin. It is proved that it causes the disorders of the coagulation system: an increase in the following factors of plasma coagulation (fibrinogen, VII, VIII, fibrinopeptide A, thrombinantithrombin complex), fibrinolysis (D-dimer), endothelium (interleukin 1, endothelin 1, vascular cell adhesion molecules, endothelial growth factor), platelet activity (von Willebrand factor, intercellular adhesion molecules, platelet factor 4, P-selectin, thromboxane A2, thromboglobulin, CD63P) and cytokines (tumor necrosis factor, interleukin 6) and decrease in E-selectin. The role of particular coagulation factors for the development of chronic heart failure has not been understood yet. Thus, it is necessary to carry out further studies. |
| Databáze: | OpenAIRE |
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