The Regulation of cGAS
| Autor: | Su-Yun Wang, Yong Ran, Mei-Guang Xiong, Yan-Yi Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Programmed cell death DNA damage Immunology Review Biology Mitochondrion Gene mutation Virus 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Virology Animals Humans Membrane Proteins DNA Nucleotidyltransferases Immunity Innate Cell biology 030104 developmental biology chemistry Gene Expression Regulation Cytoplasm Molecular Medicine Nucleotides Cyclic 030217 neurology & neurosurgery Metabolic Networks and Pathways cGAS DNA sensing Regulation Autoimmune |
| Zdroj: | Virologica Sinica |
| ISSN: | 1995-820X 1674-0769 |
| Popis: | The cGAS-MITA pathway of cytosolic DNA sensing plays essential roles in immune response against pathogens that contain DNA or with DNA production in their life cycles. The cGAS-MITA pathway also detects leaked or aberrant accumulated self DNA in the cytoplasm under certain pathological conditions, such as virus induced cell death, DNA damage, mitochondria damage, gene mutations, which results in autoimmune diseases. Therefore, the cGAS-MITA pathway must be tightly controlled to ensure proper immune response against pathogens and to avoid autoimmune diseases. The regulation of cGAS-MITA pathway at MITA-level have been extensively explored and reviewed elsewhere, here we provide a summary and perspective on recent advances in understanding of the cGAS regulation. |
| Databáze: | OpenAIRE |
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