The AMPK enzyme-complex: from the regulation of cellular energy homeostasis to a possible new molecular target in the management of chronic inflammatory disorders

Autor: Ilaria Marsilio, Erika Tirotta, Rocchina Colucci, Corrado Blandizzi, Matteo Fornai, Carolina Pellegrini, Luca Antonioli, Deborah Sacco, Zoltán Németh, Maria Cecilia Giron, Giulio Giustarini, Valentina Caputi
Rok vydání: 2015
Předmět:
lymphocytes
0301 basic medicine
Enzyme complex
medicine.medical_treatment
adenosine triphosphate
Clinical Biochemistry
Anti-Inflammatory Agents
Inflammation
AMP-Activated Protein Kinases
adenosine
adenosine monophosphate-activated protein kinase
dendritic cells
immune system
inflammation
inflammatory disease
macrophages
neutrophils
Drug Discovery3003 Pharmaceutical Science
Pharmacology
Molecular Medicine
03 medical and health sciences
AMP-activated protein kinase
Drug Discovery
medicine
Animals
Homeostasis
Humans
Macrophage
Molecular Targeted Therapy
Protein kinase A
biology
AMPK
adenosine
adenosine monophosphate-activated protein kinase
adenosine triphosphate
dendritic cells
immune system
inflammation
inflammatory disease
lymphocytes
macrophages
neutrophils
Pharmacology
Clinical Biochemistry
Molecular Medicine
Enzyme structure
Cell biology
030104 developmental biology
Cytokine
Biochemistry
Drug Design
Chronic Disease
biology.protein
medicine.symptom
Zdroj: Expert Opinion on Therapeutic Targets. 20:179-191
ISSN: 1744-7631
1472-8222
Popis: Adenosine monophosphate-activated protein kinase (AMPK), known as an enzymatic complex that regulates the energetic metabolism, is emerging as a pivotal enzyme and enzymatic pathway involved in the regulation of immune homeostatic networks. It is also involved in the molecular mechanisms underlying the pathophysiology of chronic inflammatory diseases.AMPK is expressed in several immune cell types including macrophages, lymphocytes, neutrophils and dendritic cells, and governs a broad array of cell functions, which include cytokine production, chemotaxis, cytotoxicity, apoptosis and proliferation. Based on its wide variety of immunoregulatory actions, the AMPK system has been targeted to reveal its impact on the course of immune-related diseases, such as atherosclerosis, psoriasis, joint inflammation and inflammatory bowel diseases.The identification of AMPK subunits responsible for specific anti-inflammatory actions and the understanding of the underlying molecular mechanisms will promote the generation of novel AMPK activators, endowed with improved pharmacodynamic and pharmacokinetic profiles. These new tools will aid us to utilize AMPK pathway activation in the management of acute and chronic inflammatory diseases, while minimizing potential adverse reactions related to the effects of AMPK on metabolic energy.
Databáze: OpenAIRE
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