Cytotoxic Effect of Paclitaxel Incorporated in Nanoparticles Based on Lactic and Glycolic Acid Copolymer
| Autor: | Y. M. Hamdy, E. A. Oganesyan, Renad N. Alyautdin, V. Bojat, V. Yu. Balaban’yan, D. S. Baranov |
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| Rok vydání: | 2011 |
| Předmět: |
Paclitaxel
Polymers Drinking Behavior Polysorbates Nanoparticle General Biochemistry Genetics and Molecular Biology Dosage form Jurkat Cells chemistry.chemical_compound Drug Delivery Systems Cell Line Tumor Copolymer Humans Organic chemistry Lactic Acid Cytotoxicity Glycolic acid General Medicine Antineoplastic Agents Phytogenic Controlled release In vitro Glycolates chemistry Delayed-Action Preparations Nanoparticles Nuclear chemistry |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 151:340-343 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-011-1325-9 |
| Popis: | Paclitaxel dosage form on nanoparticles of 200-300 nm based on lactic and glycolic acid copolymer was obtained by the co-precipitation method. The possibility of controlled release of paclitaxel at pH 7.4 for 24 h was studied in vitro. Studies on Jurkat/WT human T-lymphoblastic leukemia cells showed that incorporation of paclitaxel in the nanoparticles led to a 4-fold increase of its cytotoxicity (6.8×10(-6) M) in comparison with paclitaxel solution. The efficiency of compositions containing polysorbate-80 was comparable to that of non-modified nanoparticles containing paclitaxel. |
| Databáze: | OpenAIRE |
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