Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology
| Autor: | Olivier Lurette, Hala Guedouari, Jordan L. Morris, Rebeca Martín-Jiménez, Julie-Pier Robichaud, Geneviève Hamel-Côté, Mehtab Khan, Nicholas Dauphinee, Nicolas Pichaud, Julien Prudent, Etienne Hebert-Chatelain |
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| Přispěvatelé: | Hebert-Chatelain, Etienne [0000-0003-1480-2787], Apollo - University of Cambridge Repository, Prudent, Julien [0000-0003-3821-6088] |
| Rok vydání: | 2022 |
| Předmět: |
Pharmacology
Membrane Potential Mitochondrial Cellular respiration Cell Respiration Cell Biology Mitochondria Cellular and Molecular Neuroscience src-Family Kinases Mitochondrial dynamics Molecular Medicine Original Article Oxidative phosphorylation Mitochondria-shaping protein Phosphorylation Molecular Biology |
| Popis: | The architecture of mitochondria adapts to physiological contexts: while mitochondrial fragmentation is usually associated to quality control and cell death, mitochondrial elongation often enhances cell survival during stress. Understanding how these events are regulated is important to elucidate how mitochondrial dynamics control cell fate. Here, we show that the tyrosine kinase Src regulates mitochondrial morphology. Deletion of Src increased mitochondrial size and reduced cellular respiration independently of mitochondrial mass, mitochondrial membrane potential or ATP levels. Re-expression of Src targeted to the mitochondrial matrix, but not of Src targeted to the plasma membrane, rescued mitochondrial morphology in a kinase activity-dependent manner. These findings highlight a novel function for Src in the control of mitochondrial dynamics. |
| Databáze: | OpenAIRE |
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