Abnormalities of B cell subsets in patients with systemic lupus erythematosus
| Autor: | Annett M. Jacobi, Peter E. Lipsky, Jisoo Lee, Thomas Dörner |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Systemic disease
Immunology B-Lymphocyte Subsets Lymphocyte Activation Immunophenotyping Immunopathology medicine Immunology and Allergy Humans Lupus Erythematosus Systemic In patient B cell Autoimmune disease B-Lymphocytes Systemic lupus erythematosus biology business.industry medicine.disease Flow Cytometry Connective tissue disease medicine.anatomical_structure Polyclonal antibodies biology.protein business Immunologic Memory |
| Zdroj: | Journal of immunological methods. 363(2) |
| ISSN: | 1872-7905 |
| Popis: | The prototypic autoimmune disease, SLE, is known to be associated with polyclonal B cell hyperreactivity. Developing an understanding of the complex nature of human B cell differentiation, largely through the application of multiparameter flow cytometry to an analysis of circulating B cells has permitted an assessment of whether specific stages of B cell maturation are affected by the tendency for polyclonal B cell activation. Moreover, the analysis of perturbations of the specific stages of B cell maturation has generated new information on whether abnormalities in B cell differentiation are primarily involved in autoimmune disease immunopathology or, rather, are secondary to the inflammatory environment characteristic of subjects with this autoimmune disease. Multivariant analysis has begun to document abnormalities in B cell maturation that are primarily associated with lupus, or, alternatively related to disease duration, disease activity and concomitant medication. Together, these analyses have provided new insights on the role of B cell over-reactivity in SLE. |
| Databáze: | OpenAIRE |
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