LINCS Data Portal 2.0: next generation access point for perturbation-response signatures
| Autor: | Raymond Terryn, Alexander Lachmann, Vasileios Stathias, John Paul Turner, Afoma C. Umeano, Daniel J.B. Clarke, Dusica Vidovic, John Erol Evangelista, Amar Koleti, Marcin Pilarczyk, Stephan C. Schürer, Mehdi Fazel-Najafabadi, Caty Chung, Daniel J. Cooper, Avi Ma'ayan, Mario Medvedovic |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Databases
Factual Next-generation access Information Storage and Retrieval Biology 03 medical and health sciences User-Computer Interface 0302 clinical medicine Common fund Genetics Database Issue Humans Data Curation 030304 developmental biology 0303 health sciences Clinical Trials as Topic Metadata Information retrieval Data curation Extramural Computational Biology Cell Biology United States Data portal National Institutes of Health (U.S.) 030220 oncology & carcinogenesis Data architecture User interface |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program with the goal of generating a large-scale and comprehensive catalogue of perturbation-response signatures by utilizing a diverse collection of perturbations across many model systems and assay types. The LINCS Data Portal (LDP) has been the primary access point for the compendium of LINCS data and has been widely utilized. Here, we report the first major update of LDP (http://lincsportal.ccs.miami.edu/signatures) with substantial changes in the data architecture and APIs, a completely redesigned user interface, and enhanced curated metadata annotations to support more advanced, intuitive and deeper querying, exploration and analysis capabilities. The cornerstone of this update has been the decision to reprocess all high-level LINCS datasets and make them accessible at the data point level enabling users to directly access and download any subset of signatures across the entire library independent from the originating source, project or assay. Access to the individual signatures also enables the newly implemented signature search functionality, which utilizes the iLINCS platform to identify conditions that mimic or reverse gene set queries. A newly designed query interface enables global metadata search with autosuggest across all annotations associated with perturbations, model systems, and signatures. |
| Databáze: | OpenAIRE |
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