Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression

Autor: Katrina Steiling, Marc E. Lenburg, J. Sebastiaan Vroegop, Ilse M. Boudewijn, Marnix R. Jonker, Pascal Wielders, Victor Guryev, Irene H. Heijink, Huib A. M. Kerstjens, Maarten van den Berge, Erica van der Wiel, Susan J. M. Hoonhorst, Eef D. Telenga, Nick H. T. ten Hacken, Corry-Anke Brandsma, Khaled Mansour, Alen Faiz, Dirkje S. Postma, Wim Timens, Wim Boersma, Harold G. de Bruin, Avrum Spira, Henk R. Pasma, Frank van den Elshout
Přispěvatelé: Lifestyle Medicine (LM), Groningen Research Institute for Asthma and COPD (GRIAC), Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS)
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Microarray
Respiratory System
PROTEIN
Gene Expression
Mucous membrane of nose
Nasal epithelium
EMPHYSEMA
Cohort Studies
Pulmonary Disease
Chronic Obstructive
0302 clinical medicine
ENRICHMENT ANALYSIS
LUNG FIBROBLASTS
Gene expression
COPD
Genome wide gene expression
respiratory system
Middle Aged
3. Good health
medicine.anatomical_structure
Biomarker (medicine)
Female
SMOKING
Adult
Bronchial epithelium
Bronchi
OBSTRUCTIVE PULMONARY-DISEASE
03 medical and health sciences
CILIA
medicine
Humans
BIOSYNTHESIS
Gene
Aged
lcsh:RC705-779
Bronchus
business.industry
Research
PATHWAYS
lcsh:Diseases of the respiratory system
STANDARDIZATION
medicine.disease
respiratory tract diseases
Gene expression profiling
Nasal Mucosa
030104 developmental biology
030228 respiratory system
Immunology
business
Zdroj: Respiratory Research, 18:213. BioMed Central Ltd.
Respiratory Research, Vol 18, Iss 1, Pp 1-10 (2017)
Respiratory Research
ISSN: 1465-9921
Popis: Nasal gene expression profiling is a promising method to characterize COPD non-invasively. We aimed to identify a nasal gene expression profile to distinguish COPD patients from healthy controls. We investigated whether this COPD-associated gene expression profile in nasal epithelium is comparable with the profile observed in bronchial epithelium. Genome wide gene expression analysis was performed on nasal epithelial brushes of 31 severe COPD patients and 22 controls, all current smokers, using Affymetrix Human Gene 1.0 ST Arrays. We repeated the gene expression analysis on bronchial epithelial brushes in 2 independent cohorts of mild-to-moderate COPD patients and controls. In nasal epithelium, 135 genes were significantly differentially expressed between severe COPD patients and controls, 21 being up- and 114 downregulated in COPD (false discovery rate
Databáze: OpenAIRE
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