Effects of the Japanese herbal medicine Keishi-bukuryo-gan and 17beta-estradiol on calcitonin gene-related peptide-induced elevation of skin temperature in ovariectomized rats
| Autor: | JT Chen, M Noguchi, A Ishige, Yasushi Ikarashi, M Yuzurihara, Satoshi Takeda, M Aburada, Y Kase |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Calcitonin Gene-Related Peptide Injections Subcutaneous Ovariectomy Endocrinology Diabetes and Metabolism Administration Oral Endogeny Calcitonin gene-related peptide Rats Sprague-Dawley Endocrinology Internal medicine medicine Animals Receptor Medicine East Asian Traditional Dose-Response Relationship Drug Estradiol integumentary system business.industry Skin temperature 17beta estradiol Rats Estrogen Calcitonin Hot Flashes Ovariectomized rat Female Skin Temperature business Drugs Chinese Herbal Receptors Calcitonin Gene-Related Peptide |
| Zdroj: | Journal of Endocrinology. 176:359-366 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1677/joe.0.1760359 |
| Popis: | The effects of a Japanese herbal medicine, Keishi-bukuryo-gan, and 17beta-estradiol on calcitonin gene-related peptide (CGRP)-induced elevation of skin temperature were investigated in ovariectomized (OVX) rats. Ovariectomy not only potentiated CGRP-induced elevation of skin temperature and arterial vasorelaxation but also induced a lower concentration of endogenous CGRP in plasma and up-regulation of arterial CGRP receptors, suggesting that lowered CGRP in plasma due to ovarian hormone deficiency increases the number of CGRP receptors and consequently amplifies the stimulatory effects of CGRP to elevate skin temperature. Oral Keishi-bukuryo-gan (100-1000 mg/kg, once a day for 7 days) restored a series of CGRP-related responses observed in OVX rats by normalizing plasma CGRP levels in a dose-dependent manner as effectively as s.c. injection. 17Beta-estradiol (0.010 mg/kg, once a day for 7 days). However, Keishi-bukuryo-gan did not affect the lower concentration of plasma estradiol and the decreased uterine weight due to ovariectomy, although the hormone replacement of 17beta-estradiol restored them. These results suggest that Keishi-bukuryo-gan, which does not confer estrogen activity on plasma, may be useful for the treatment of hot flashes in patients for whom estrogen replacement therapy is contraindicated, as well as menopausal women. |
| Databáze: | OpenAIRE |
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