Low antibody prevalence against Bacillus cereus biovar anthracis in Taï National Park, Côte d'Ivoire, indicates high rate of lethal infections in wildlife
| Autor: | Roman M. Wittig, Jan F. Gogarten, Roland Grunow, Susanne M. Köhler, Alexander Lang, Fabian H. Leendertz, Silke R. Klee, Ariane Düx, Hélène M. De Nys, Kathrin Nowak, Fee Zimmermann, Emmanuel Couacy-Hymann, Susann Dupke, Anne Barduhn |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Bacterial Diseases Physiology Biovar Parks Recreational Bacillus cereus Monkeys Wildlife Biochemistry Serology 0302 clinical medicine Zoonoses Immune Physiology Prevalence Medicine and Health Sciences Enzyme-Linked Immunoassays Red colobus Mammals Immune System Proteins biology Virulence National park Organic Compounds lcsh:Public aspects of medicine Eukaryota Haplorhini Ruminants Antibodies Bacterial 3. Good health Chemistry Infectious Diseases Cereus Vertebrates Physical Sciences Apes Picric Acid Research Article Primates lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Animal Types 030231 tropical medicine Immunology Colobus Research and Analysis Methods Antibodies Anthrax 03 medical and health sciences Phenols Old World monkeys Animals Chimpanzees Immunoassays Nitrobenzenes fungi Organic Chemistry Public Health Environmental and Occupational Health Organisms Chemical Compounds Biology and Life Sciences Proteins lcsh:RA1-1270 biology.organism_classification Virology 030104 developmental biology Cote d'Ivoire Amniotes Immunologic Techniques Acids Zoology |
| Zdroj: | PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005960 (2017) |
| ISSN: | 1935-2735 |
| Popis: | Bacillus cereus biovar anthracis (Bcbva) is a member of the B. cereus group which carries both B. anthracis virulence plasmids, causes anthrax-like disease in various wildlife species and was described in several sub-Saharan African rainforests. Long-term monitoring of carcasses in Taï National Park, Côte d’Ivoire, revealed continuous wildlife mortality due to Bcbva in a broad range of mammalian species. While non-lethal anthrax infections in wildlife have been described for B. anthracis, nothing is known about the odds of survival following an anthrax infection caused by Bcbva. To address this gap, we present the results of a serological study of anthrax in five wildlife species known to succumb to Bcbva in this ecosystem. Specific antibodies were only detected in two out of 15 wild red colobus monkeys (Procolobus badius) and one out of 10 black-and-white colobus monkeys (Colobus polykomos), but in none of 16 sooty mangabeys (Cercocebus atys), 9 chimpanzees (Pan troglodytes verus) and 9 Maxwell’s duikers (Cephalophus maxwellii). The combination of high mortality and low antibody detection rates indicates high virulence of this disease across these different mammalian species. Author summary Anthrax is a deadly zoonosis, predominantly known to affect wild and domestic herbivores. It has long been assumed that the disease is exclusively caused by B. anthracis, but recently another member of the B. cereus group, Bacillus cereus biovar anthracis (Bcbva), was found to carry both B. anthracis virulence plasmids. Bcbva causes anthrax-like disease in wildlife throughout sub-Saharan Africa and was shown to be an important cause of wildlife mortality in Taï National Park, Cote d’Ivoire, affecting a broad range of mammalian species. While mortality data has routinely been collected in the area for decades, it remains unknown whether non-lethal Bcbva exposure occurs. We therefore conducted a serological study in four primate and one duiker species in which Bcbva-related fatalities were previously documented. Frequent non-lethal exposure should result in a high antibody seroprevalence within wildlife populations, while high lethality would result in low antibody seroprevalence. We found that antibody detection rates were low, suggesting that Bcbva infections in these species are likely often lethal. |
| Databáze: | OpenAIRE |
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