Atypical Mutation in Neisseria gonorrhoeae 23S rRNA Associated with High-Level Azithromycin Resistance
| Autor: | Henrietta Hardin, Aaron Olsen, Brad Roland, Ellen N. Kersh, Ruth Sanon, Samera Sharpe, Jonathan S. Carlson, Brian H. Raphael, Grace Woods, Olusegun O. Soge, Hsi Liu, Evelyn E. Nash, Karen Schlanger, Matthew W. Schmerer, Sancta B. St. Cyr, Cau D. Pham, Kevin Sellers |
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| Rok vydání: | 2021 |
| Předmět: |
Microbial Sensitivity Tests
Azithromycin Biology medicine.disease_cause Genetic analysis Microbiology Gonorrhea 03 medical and health sciences Antibiotic resistance Mechanisms of Resistance 23S ribosomal RNA Drug Resistance Bacterial Genotype medicine Humans Pharmacology (medical) Allele Gene 030304 developmental biology Pharmacology 0303 health sciences 030306 microbiology Neisseria gonorrhoeae Anti-Bacterial Agents RNA Ribosomal 23S Infectious Diseases Mutation Mutation (genetic algorithm) |
| Zdroj: | Antimicrob Agents Chemother |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.00885-20 |
| Popis: | A2059G mutation in the 23S rRNA gene is the only reported mechanism conferring high-level azithromycin resistance (HL-AZMR) in Neisseria gonorrhoeae . Through U.S. gonococcal antimicrobial resistance surveillance projects, we identified four HL-AZMR gonococcal isolates lacking this mutational genotype. Genetic analysis revealed an A2058G mutation of 23S rRNA alleles in all four isolates. In vitro selected gonococcal strains with homozygous A2058G recapitulated the HL-AZMR phenotype. |
| Databáze: | OpenAIRE |
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