Does Haptoglobin Phenotype Influence Postnatal Morbidity in Preterm Neonates?
| Autor: | Rachel Miller-Lotan, Shany Blum, Andrew P. Levy, Dan Waisman, Irena Kessel, Eyal Jacobson, Maayan Leib, Avi Rotschild |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Population Infant Premature Diseases Polymerase Chain Reaction Gastroenterology Cohort Studies Sepsis Enterocolitis Necrotizing Risk Factors Internal medicine medicine Humans Retinopathy of Prematurity Prospective Studies Israel education Bronchopulmonary Dysplasia Cerebral Hemorrhage education.field_of_study Haptoglobins biology business.industry Haptoglobin Infant Newborn Obstetrics and Gynecology Gestational age Retinopathy of prematurity Protective Factors medicine.disease Phenotype Intraventricular hemorrhage Bronchopulmonary dysplasia Pediatrics Perinatology and Child Health Immunology Necrotizing enterocolitis biology.protein Electrophoresis Polyacrylamide Gel Female business Infant Premature |
| Zdroj: | American Journal of Perinatology. 33:130-135 |
| ISSN: | 1098-8785 0735-1631 |
| DOI: | 10.1055/s-0035-1560042 |
| Popis: | Background Haptoglobin (Hp) is an acute phase protein with antioxidant, bacteriostatic, and anti-inflammatory activities. Hp proteins associated with the three major phenotypes differ in their proinflammatory and anti-inflammatory action. Inflammation and oxidative stress are both involved in most pathophysiological processes in premature infants. The objective of this study was to determine whether Hp phenotype influences clinical manifestations and sepsis incidence in the premature infants. Objective Infants born before 35 weeks gestational age were prospectively evaluated for Hp phenotype and clinical events, including sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, intraventricular hemorrhage, and retinopathy of prematurity. The participants were observed until discharge. Methods A total of 122 preterm infants were enrolled in the study. Clinical events were not affected by the Hp phenotype. The expression of Hp protein was extremely low in the study population. More septic episodes were found in infants with a birth weight greater than 1,500 g, although, the difference was not statistically significant. Results Extremely low expression of Hp may explain the lack of a correlation between Hp phenotype and sepsis in preterm infants. Further research involving a larger neonatal population is required to better understand the role of the Hp phenotype in morbidity of premature infants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|