Somatomedin C (insulin-like growth factor I) levels in patients with chronic fatigue syndrome
| Autor: | Darrel M. Mayes, Anthony L. Komaroff, Laura R. Fagioli, Rosanne T. Guerriero, Adrienne L. Bennett |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Fibromyalgia animal structures Somatotropic cell medicine.medical_treatment Radioimmunoassay Insulin-like growth factor Internal medicine medicine Chronic fatigue syndrome Humans Insulin-Like Growth Factor I Biological Psychiatry chemistry.chemical_classification Sleep disorder Fatigue Syndrome Chronic business.industry Middle Aged medicine.disease Somatomedin humanities Psychiatry and Mental health Endocrinology chemistry Female business hormones hormone substitutes and hormone antagonists Tricyclic |
| Zdroj: | Journal of Psychiatric Research. 31:91-96 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/s0022-3956(96)00056-8 |
| Popis: | Chronic fatigue syndrome is a disorder clinically quite similar to fibromyalgia syndrome, and it is of interest to examine if these two syndromes have pathogenetic as well as clinical features in common. Somatomedin C levels have been found to be lower in patients with fibromyalgia syndrome than in healthy controls. An attractive hypothesis relating sleep disturbance, altered somatotropic neuroendocrine function and fibromyalgia symptoms has been put forward as a plausible pathogenic mechanism for fibromyalgia syndrome. We therefore sought to investigate the level of somatomedin C in patients with chronic fatigue syndrome. Somatomedin C levels were determined by radioimmunoassay in frozen serum specimens from 49 patients with CFS and 30 healthy blood donor control subjects of similar age and gender. Somatomedin C levels were higher in patients with CFS than in healthy control subjects (255.3 +/- 68.5 vs 211.9 +/- 76.2, P = 0.01). There was no effect of gender, use of nonsteroidal anti-inflammatory drugs or tricyclic drugs on levels of somatomedin C. There was a tendency for somatomedin C levels to fall with age. In contrast to patients with fibromyalgia, in whom levels of somatomedin C have been found to be reduced, levels in patients with CFS were found to be elevated. Thus, despite the clinical similarities between these two conditions, they may be associated with different abnormalities of sleep and/or of the somatotropic neuroendocrine axis. |
| Databáze: | OpenAIRE |
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