Multi-trichothecene mycotoxin exposure activates glutathione-redox system in broiler chicken
| Autor: | Krisztián Balogh, Márta Erdélyi, Csilla Pelyhe, Erika Zándoki, Benjámin Kövesi, Balázs Kovács, Szabina Kulcsár, Miklós Mézes |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.medical_treatment Gene Expression Food Contamination Toxicology GPX4 medicine.disease_cause Antioxidants Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology medicine Animals Food science Mycotoxin Glutathione Peroxidase Chemistry Toxin Broiler 04 agricultural and veterinary sciences Glutathione Animal Feed 040401 food science Oxidative Stress T-2 Toxin 030104 developmental biology Liver Lipid Peroxidation Trichothecenes Chickens Oxidation-Reduction Oxidative stress |
| Zdroj: | Toxicon. 153:53-57 |
| ISSN: | 0041-0101 |
| DOI: | 10.1016/j.toxicon.2018.08.010 |
| Popis: | Co-occurrence of mycotoxin contamination of feeds is a frequent problem, therefore the purpose of this study was to evaluate the combined effect of T-2 toxin and deoxynivalenol (DON) on lipid peroxidation, parameters and regulation of the glutathione redox system in broiler chickens in a sub-chronic (7 day) study. The applied doses were: low mix: 0.23 mg T-2 toxin and 4.96 mg DON/kg feed; medium mix: 1.21 mg T-2 toxin and 12.38 mg DON/kg feed; and high mix: 2.42 T-2 toxin and 24.86 mg DON/kg feed. Liver samples were taken on days 0, 1, 2, 3, and 7 of the feeding trial. Lipid peroxidation decreased significantly as compared to the control on days 3 and 7 as effect of low and high doses, which can be related to the activation of the antioxidant system, which is supported by the elevated glutathione peroxidase activity and reduced glutathione concentration as compared to the control on day 3 in the medium and high dose groups. Gene expression of glutathione peroxidase 4 (GPX4) elevated on day 1 in a dose dependent manner, and showed continuous elevation in the highest dose group thereafter. The results suggested that common exposure of T-2 toxin and DON induced oxidative stress in the liver of broiler chickens, which activated the enzymatic antioxidant system, and consequently decreased lipid peroxidation. |
| Databáze: | OpenAIRE |
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