Atopic sensitization and the international variation of asthma symptom prevalence in children
| Autor: | Riccardo Di Domenicantonio, Elpis Hatziagorou, Luis Garcia-Marcos, Erika Von Mutius, Lennart Nilsson, RENATO STEIN, Francesco Forastiere, Neil Pearce, Hywel Williams, Maia Gotua, Antonio Martínez-Gimeno, Philippa Ellwood, Lennart Bråbäck, Javier Mallol, Bert Brunekreef, Richard Beasley, Gary Wong, Marianne Van Hage, Raju Khubchandani, Manuela De Sario |
|---|---|
| Přispěvatelé: | Institute of Epidemiology, Universität Ulm - Ulm University [Ulm, Allemagne], Institute of Environmental Medicine, Karolinska Institutet [Stockholm], Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], Pediatric Pulmonology and Allergy, Virgen de la Arrixaca University Children's Hospital, Asthma and Allergy Department, University Children's Hospital-Ludwig-Maximilians University [Munich] (LMU), Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), SK Weiland, von Mutius E, MA Riikjärv, P Rzehak, RT Stein, DP Strachan, Tsanakas J, K Wickens, Wong GW, Phase Deux Groupe d'étude ISAAC . Collaborateurs (158) Bjorksten B, W Cookson, B Bjorksten, D Strachan, Dentler C, Kleiner A, G Weinmayr, Priftanji A, A Shkurti, Simenati J, Grabocka E, Shyti K, S Agolli, B Brunekreef, Gurakuqi A, Urrutia de Pereira M, MH Jones, PM Pitrez, Cooper PJ, M Chico, YZ Chen, Zhong NS, C Lai, Wong G, G Büchele, T Annus, Annesi-Maesano I, M Rukhadze, T Abramidze, Kvachadze I, L Karsanidze, M Kiladze, N Dolidze, W Leupold, U Keil, WO Cookson, S Weiland, P Arthur, Addo- E Yobo, C Priftis, Papadopoulou A, C Katsardis, E Hatziagorou, Kirvassillis F, M Claus, Marcos-Garcia L, M Gotua, C Gratziou, M Hage van, University Children's Hospital-Ludwig Maximilians University |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Hypersensitivity
Immediate Rural Population Allergy Pediatrics Urban Population MESH: Asthma MESH: Antibodies Anti-Idiotypic Critical Care and Intensive Care Medicine Global Health Atopy 0302 clinical medicine MESH: Rural Population Risk Factors MESH: Risk Factors MESH: Child Odds Ratio Prevalence 030212 general & internal medicine Child MESH: Immunoglobulin E Prognosis 3. Good health Antibodies Anti-Idiotypic MESH: Urban Population medicine.symptom MESH: Hypersensitivity Immediate Pulmonary and Respiratory Medicine medicine.medical_specialty MESH: Socioeconomic Factors MESH: Prognosis 03 medical and health sciences MESH: Cross-Sectional Studies Wheeze Environmental health Intensive care medicine Humans Risk factor MESH: Prevalence Asthma MESH: Humans business.industry Immunoglobulin E medicine.disease MESH: Odds Ratio Cross-Sectional Studies 030228 respiratory system El Niño Socioeconomic Factors Attributable risk [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business MESH: World Health |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine American Journal of Respiratory and Critical Care Medicine, 2007, 176 (6), pp.565-74. ⟨10.1164/rccm.200607-994OC⟩ American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2007, 176 (6), pp.565-74. ⟨10.1164/rccm.200607-994OC⟩ |
| ISSN: | 1073-449X 1535-4970 |
| DOI: | 10.1164/rccm.200607-994OC⟩ |
| Popis: | International audience; RATIONALE: Atopic sensitization has long been known to be related to asthma in children, but its role in determining asthma prevalence remains to be elucidated further. OBJECTIVES: To investigate the role of atopic sensitization in the large international variation in the prevalence of childhood asthma. METHODS: Cross-sectional studies of random samples of 8- to 12-year-old children (n = 1,000 per center) were performed according to the standardized methodology of Phase Two of the International Study of Asthma and Allergy in Childhood (ISAAC). Thirty study centers in 22 countries worldwide participated and reflect a wide range of living conditions, from rural Africa to urban Europe. Data were collected by parental questionnaires (n = 54,439), skin prick tests (n = 31,759), and measurements of allergen-specific IgE levels in serum (n = 8,951). Economic development was assessed by gross national income per capita (GNI). MEASUREMENTS AND MAIN RESULTS: The prevalence of current wheeze (i.e., during the past year) ranged from 0.8% in Pichincha (Ecuador) to 25.6% in Uruguaiana (Brazil). The fraction of current wheeze attributable to atopic sensitization ranged from 0% in Ankara (Turkey) to 93.8% in Guangzhou (China). There were no correlations between prevalence rates of current wheeze and atopic sensitization, and only weak correlations of both with GNI. However, the fractions and prevalence rates of wheeze attributable to skin test reactivity correlated strongly with GNI (Spearman rank-order coefficient rho = 0.50, P = 0.006, and rho = 0.74, P < 0.0001, respectively). In addition, the strength of the association between current wheeze and skin test reactivity, assessed by odds ratios, increased with GNI (rho = 0.47, P = 0.01). CONCLUSIONS: The link between atopic sensitization and asthma symptoms in children differs strongly between populations and increases with economic development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|