Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells
Autor: | Shingo Kasamatsu, Takaaki Akaike, Hozumi Motohashi, Tetsuro Matsunaga, Motohiro Nishida, Akiyuki Nishimura |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Cell signaling 030204 cardiovascular system & hematology Sulfides Nitric Oxide Biochemistry Redox Protein Aggregation Pathological Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine GTP-Binding Proteins Physiology (medical) Animals Humans Myocytes Cardiac Cysteine Disulfides Cyclic GMP chemistry.chemical_classification Reactive oxygen species Chemistry Myocardium Metabolism Glutathione KEAP1 Oxidative Stress 030104 developmental biology Gene Expression Regulation Electrophile Cardiomyopathies Reactive Oxygen Species Oxidation-Reduction Signal Transduction |
Zdroj: | Free radical biologymedicine. 109 |
ISSN: | 1873-4596 |
Popis: | Maintaining a redox balance by means of precisely controlled systems that regulate production, and elimination, and metabolism of electrophilic substances (electrophiles) is essential for normal cardiovascular function. Electrophilic signaling is mainly regulated by endogenous electrophiles that are generated from reactive oxygen species, nitric oxide, and the derivative reactive species of nitric oxide during stress responses, as well as by exogenous electrophiles including compounds in foods and environmental pollutants. Among electrophiles formed endogenously, 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP) has unique cell signaling functions, and pathways for its biosynthesis, signaling mechanism, and metabolism in cells have been clarified. Reactive persulfide species such as cysteine persulfides and polysulfides that are endogenously produced in cells are likely to be involved in 8-nitro-cGMP metabolism. These new aspects of redox biology may stimulate innovative and multidisciplinary research in cardiovascular physiology and pathophysiology. In our review, we focus on the redox-dependent regulation of electrophilic signaling via reduction and metabolism of electrophiles by reactive persulfides in cardiac cells, and we include suggestions for a new therapeutic strategy for cardiovascular disease. |
Databáze: | OpenAIRE |
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