Dengue viremia kinetics in asymptomatic and symptomatic infection
| Autor: | Kajohnpong Manopwisedjaroen, Veasna Duong, Anavaj Sakuntabhai, Tawatchai Yingtaweesak, Swangjit Suraamornkul, Nada Pitabut, Pratap Singhasivanon, Richard Paul, Ponpan Matangkasombut, Sasikanya Thaloengsok |
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| Přispěvatelé: | Mahidol University [Bangkok], Vajira Hospital [Bangkok], Thasongyang Hospital [Tak, Thaïland], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Génétique fonctionnelle des maladies infectieuses - Functional Genetics of Infectious Diseases, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), This study was supported by the European Union Seventh Framework Program (FP7/2007–2013) [under Grant Agreement #282,378 (DENFREE)] (to AS, RP, PS, PM) and a National Research University grant (Mahidol, to AS, PM)., European Project: 282378,EC:FP7:HEALTH,FP7-HEALTH-2011-single-stage,DENFREE(2012) |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male viruses MESH: Dengue Dengue virus medicine.disease_cause MESH: Dengue Virus Dengue fever Dengue 0302 clinical medicine MESH: Child 030212 general & internal medicine Child [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases Denv serotypes MESH: Kinetics Virus kinetics Transmission (medicine) virus diseases General Medicine Inapparent 3. Good health Asymptomatic Infectious Diseases MESH: Young Adult Female medicine.symptom Clearance Microbiology (medical) Adult medicine.medical_specialty Adolescent 030106 microbiology Viremia Serogroup lcsh:Infectious and parasitic diseases 03 medical and health sciences Young Adult Internal medicine medicine Humans lcsh:RC109-216 MESH: Viremia MESH: Adolescent MESH: Humans business.industry MESH: Adult MESH: Serogroup Dengue Virus medicine.disease MESH: Male Kinetics Viral decay business MESH: Female Viremia duration |
| Zdroj: | International Journal of Infectious Diseases, Vol 101, Iss, Pp 90-97 (2020) International Journal of Infectious Diseases International Journal of Infectious Diseases, 2020, 101, pp.90-97. ⟨10.1016/j.ijid.2020.09.1446⟩ |
| ISSN: | 1878-3511 1201-9712 |
| DOI: | 10.1016/j.ijid.2020.09.1446⟩ |
| Popis: | International audience; Background: Dengue infection is a global health threat. While symptomatic cases contribute to morbidity and mortality, the majority of infected people are asymptomatic but serve as an important reservoir. However, the kinetics of viremia in asymptomatic infections remains unknown. Methods: We enrolled 279 hospital-based symptomatic index cases and quantified dengue virus (DENV) RNA at enrollment and at the day of defervescence. To identify asymptomatic cases, 175 household members of index cases were monitored for clinical symptoms during follow-up, and blood was taken twice weekly to test for and quantify DENV RNA until cleared. Results: We detected DENV in thirteen asymptomatic household members (7.43%). Their DENV serotypes were primarily the same as those of their family index cases. The median peak DENV viremia in asymptomatic subjects was lower than that of symptomatic individuals during the febrile phase, and the viral decay rate was slower in asymptomatic infections. Conclusions: DENV level and kinetics in asymptomatic individuals differed significantly from those of symptomatic cases. Despite the lower viremia, the slower decay rate in asymptomatic infections could lead to their prolonging the infectious reservoir. The improvement of transmission control to prevent such long-lived asymptomatic infections from transmitting the DENV is needed. |
| Databáze: | OpenAIRE |
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