Estimates and Determinants of SARS-Cov-2 Seroprevalence and Infection Fatality Ratio Using Latent Class Analysis: The Population-Based Tirschenreuth Study in the Hardest-Hit German County in Spring 2020
| Autor: | Wagner, Ralf, Peterhoff, David, Beileke, Stephanie, Günther, Felix, Berr, Melanie, Einhauser, Sebastian, Schütz, Anja, Niller, Hans-Helmut, Steininger, Philipp, Knöll, Antje, Tenbusch, Matthias, Maier, Clara, Kabesch, Michael, Schedl, Holger, Küchenhoff, Helmut, Pfahlberg, Annette B., Heid, Iris M., Gefeller, Olaf, Überla, Klaus, Korn, Klaus, Stark, Klaus J., Gessner, Andre, Burkhardt, Ralph |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Adolescent 610 Medizin Antibodies Viral Microbiology Article smoking Young Adult Seroepidemiologic Studies Germany Surveys and Questionnaires latent class analysis infection fatality ratio Humans antibodies Prospective Studies ddc:610 Aged Aged 80 and over SARS-CoV-2 seroprevalence ELISA CLIA underreported infections senior care homes COVID-19 Middle Aged QR1-502 Population Surveillance Female Seasons |
| Zdroj: | Viruses Viruses, Vol 13, Iss 1118, p 1118 (2021) Volume 13 Issue 6 |
| Popis: | SARS-CoV-2 infection fatality ratios (IFR) remain controversially discussed with implications for political measures. The German county of Tirschenreuth suffered a severe SARS-CoV-2 outbreak in spring 2020, with particularly high case fatality ratio (CFR). To estimate seroprevalence, underreported infections, and IFR for the Tirschenreuth population aged ≥14 years in June/July 2020, we conducted a population-based study including home visits for the elderly, and analyzed 4203 participants for SARS-CoV-2 antibodies via three antibody tests. Latent class analysis yielded 8.6% standardized county-wide seroprevalence, a factor of underreported infections of 5.0, and 2.5% overall IFR. Seroprevalence was two-fold higher among medical workers and one third among current smokers with similar proportions of registered infections. While seroprevalence did not show an age-trend, the factor of underreported infections was 12.2 in the young versus 1.7 for ≥85-year-old. Age-specific IFRs were < 0.5% below 60 years of age, 1.0% for age 60–69, and 13.2% for age 70+. Senior care homes accounted for 45% of COVID-19-related deaths, reflected by an IFR of 7.5% among individuals aged 70+ and an overall IFR of 1.4% when excluding senior care home residents from our computation. Our data underscore senior care home infections as key determinant of IFR additionally to age, insufficient targeted testing in the young, and the need for further investigations on behavioral or molecular causes of the fewer infections among current smokers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|