Intravenous ibuprofen blocks the hypoxemia of pulmonary glass bead embolism in the dog
| Autor: | James E. Calvin, Geoff Dervin |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Partial Pressure
Blood Pressure Ibuprofen Lung injury Critical Care and Intensive Care Medicine Hypoxemia Dogs medicine.artery medicine Animals Cardiac Output Hypoxia business.industry Oxygenation medicine.disease Pulmonary embolism Oxygen medicine.anatomical_structure Embolism Anesthesia Pulmonary artery Vascular resistance Vascular Resistance Glass medicine.symptom business Pulmonary Embolism medicine.drug |
| Zdroj: | Critical care medicine. 16(9) |
| ISSN: | 0090-3493 |
| Popis: | To determine the influence of arachidonic acid metabolites on acute lung injury induced by glass bead embolism, two groups of animals were studied before and after the pulmonary artery pressure was doubled by glass bead embolism. One group represented an untreated time control (n = 6) while the second group (n = 6) was pretreated with 25 mg/kg of iv ibuprofen. Repeat measurements were taken at 30, 60 and 90 min after glass bead embolism. Compared to the untreated group, the pretreated group had only a slightly decreased PaO2 (pretreated, 82% of baseline vs. untreated, 35% of baseline, p less than .05). The initial elevation in pulmonary vascular resistance (PVR) was similar in both groups but in the pretreated group it had returned nearly to baseline values by the end of the study in contrast to the persistent elevation of the PVR observed in the untreated group. We conclude that pretreatment with ibuprofen resulted in improved arterial oxygenation and a reduction in PVR over the time period studied. This implicates a role for arachidonic acid metabolites in the pathophysiology of this injury. |
| Databáze: | OpenAIRE |
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