Characteristics, Prognostic Factors, and Survival of Patients with NK/T-Cell Lymphoma of Non-upper Aerodigestive Tract: A 17-Year Single-Center Experience
| Autor: | De Xin Lei, Wen Qi Jiang, Hang Yang, Yan Gao, Xue Wen Zhang, Ze Long Liu, Yi Xia, Pan Pan Liu, Yuan Xue Jiang, Xi Wen Bi |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Cancer Research medicine.medical_specialty Adolescent Survival Prognostic factors Single Center Gastroenterology Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine International Prognostic Index Extranodal NK-T-Cell Lymphoma Internal medicine Humans Medicine T-cell lymphoma Non-upper aerodigestive tract Child Aged Neoplasm Staging Retrospective Studies Aged 80 and over L-Lactate Dehydrogenase Performance status business.industry Disease Management Infant Middle Aged Prognosis medicine.disease Survival Analysis Lymphoma Gastrointestinal Tract Lymphoma Extranodal NK-T-Cell 030104 developmental biology Oncology Aerodigestive Tract B symptoms Child Preschool 030220 oncology & carcinogenesis Cohort Female Original Article medicine.symptom business |
| Zdroj: | Cancer Research and Treatment : Official Journal of Korean Cancer Association |
| ISSN: | 2005-9256 1598-2998 |
| DOI: | 10.4143/crt.2018.681 |
| Popis: | PURPOSE The extranodal natural killer (NK)/T-cell lymphoma (NKTCL) of non-upper aerodigestive tract (NUAT) was found to have clinical heterogeneity compared with NKTCL of the upper aerodigestive tract (UAT) in small scale studies. We conducted this study in a much larger cohort to analyze the clinical characteristics, prognostic factors, treatment modality, and clinical outcomes of patients with NUAT-NKTCL. Materials and Methods From January 2001 to December 2017, a total of 757 NKTCL patients were identified and included in this study, including 92 NUAT-NKTCL patients (12.2%) and 665 UAT-NKTCL patients (87.8%). RESULTS NUAT-NKTCL patients had relatively poorer performance status, more unfavorable prognostic factors, and more advanced stage, compared with UAT-NKTCL patients. The 5-year overall survival (OS) was 34.7% for NUAT-NKTCL, which was significantly worse than UAT-NKTCL (64.2%, p |
| Databáze: | OpenAIRE |
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