Low serum cobalamin levels in a population study of 70- and 75-year-old subjects
| Autor: | Jan Westin, Christer Åhren, Göran Lindstedt, Sten Landahl, Lisbeth Netterblad, Herman Nilsson-Ehle, Reinhold Stockbruegger |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Aging medicine.medical_specialty Anemia Megaloblastic Gastrointestinal Diseases Physiology Anemia Atrophic gastritis Schilling Test Cobalamin Gastroenterology chemistry.chemical_compound Schilling test Internal medicine Anemia Pernicious Gastrins medicine Humans Anemia Macrocytic Vitamin B12 Megaloblastic anemia Aged pernicious anemia Pepsinogens medicine.diagnostic_test business.industry Bone Marrow Examination Endoscopy medicine.disease Vitamin B 12 chemistry Female Macrocytic anemia business Digestive System |
| Zdroj: | Digestive Diseases and Sciences. 34:716-723 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/bf01540343 |
| Popis: | We examined causes and hematological consequences of low serum cobalamin (vitamin B12) concentration in two representative population samples of 70-year-old (N = 293) and 75-year-old subjects (N = 486). Subjects with values below 130 pmol/liter (4.8% and 5.6%, respectively) were investigated with Schilling test, upper gastrointestinal endoscopy, determination of serum gastrin and group I pepsinogens, and bone marrow examination. Gastrointestinal abnormalities of etiologic significance were found in 26 of the 32 examined subjects: atrophy of the gastric body mucosa (N = 16, with pernicious anemia in six), partial gastrectomy (N = 6), and intestinal malabsorption (N = 4). Megaloblastic hematopoiesis was found in 10 individuals, four of whom had macrocytic anemia. Our results indicate that low serum cobalamin concentration in the elderly is usually a consequence of disease rather than of high age per se and that gastric mucosal atrophy is a major etiologic factor. |
| Databáze: | OpenAIRE |
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