Allopurinol-induced Drug Reactions with Eosinophilia and Systemic Symptoms Syndrome with Interstitial Nephritis
Autor: | J Fatihi, T Aatif, H El Annaz, O Qamouss |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
medicine.medical_specialty
Interstitial nephritis Allopurinol Case Report lcsh:RC870-923 Asymptomatic 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Cervical lymphadenopathy medicine Eosinophilia 030203 arthritis & rheumatology business.industry drug reactions with eosinophilia and systemic symptoms lcsh:Diseases of the genitourinary system. Urology medicine.disease Rash Dermatology Nephrology Anuria human herpesvirus 6 Azotemia medicine.symptom hypersensitivity business interstitial nephritis medicine.drug |
Zdroj: | Indian Journal of Nephrology Indian Journal of Nephrology, Vol 28, Iss 6, Pp 477-481 (2018) |
ISSN: | 1998-3662 0971-4065 |
Popis: | Allopurinol-induced drug reactions with eosinophilia and systemic symptoms (DRESS) is a severe illness related to hypersensitivity syndrome characterized by fever, skin rash, lymph node enlargement, hematological abnormalities, especially eosinophilia and atypical lymphocytosis, and single or multiple organ involvement. The syndrome is difficult to diagnose in view of its clinical heterogeneity and long latency period within 8 weeks after start treatment. We report a case of DRESS syndrome in a 64-year-old man, induced by allopurinol treatment for asymptomatic hyperuricemia, started 8 weeks earlier but stopped only 3 days after because of the onset of rash. The diagnosis was retained due to combining of interstitial nephritis with the clinical findings of fever, skin rash, cervical lymphadenopathy, eosinophilia, and reactivation of human herpesviruses specifically HHV-6. The glucocorticoids were started to relieve hypersensitivity. Five days later, the patient became afebrile, and the rash improved significantly. However, interstitial nephritis with renal function impairment progressed to severe azotemia, and even anuria requiring hemodialysis. Allopurinol-induced DRESS syndrome is associated with significant mortality, and care must, therefore, be exercised when given this drug. |
Databáze: | OpenAIRE |
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