Acute kidney injury is associated with microvascular myocardial damage following myocardial infarction

Autor: Andreas Kronbichler, Bernhard Metzler, Veronika Innerhofer, Gert Mayer, Agnes Mayr, Hans-Josef Feistritzer, Gert Klug, Martin Tiefenthaler, Martin Reindl, Sebastian Johannes Reinstadler
Rok vydání: 2016
Předmět:
Male
medicine.medical_specialty
medicine.medical_treatment
Infarction
Contrast Media
Gadolinium
030204 cardiovascular system & hematology
urologic and male genital diseases
Kidney
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Percutaneous Coronary Intervention
Interquartile range
Risk Factors
Internal medicine
medicine
Odds Ratio
Humans
cardiovascular diseases
030212 general & internal medicine
Myocardial infarction
Aged
Creatinine
Ejection fraction
business.industry
Myocardium
Acute kidney injury
Age Factors
Percutaneous coronary intervention
Heart
Stroke Volume
Stroke volume
Acute Kidney Injury
Middle Aged
medicine.disease
Coronary Vessels
Magnetic Resonance Imaging
chemistry
Nephrology
Microvessels
Multivariate Analysis
cardiovascular system
Cardiology
ST Elevation Myocardial Infarction
Female
Hypertrophy
Left Ventricular
business
Zdroj: Kidney international. 92(3)
ISSN: 1523-1755
Popis: Acute kidney injury (AKI) is a frequent complication in patients with ST-elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention. However, the pathophysiology of AKI in this setting is complex and goes beyond the administration of contrast media. Studies assessing the impact of infarct characteristics on AKI are currently lacking. Therefore, we investigated the association of AKI with myocardial as well as microvascular injury in an initial total of 361 consecutive STEMI patients treated by primary percutaneous coronary intervention. Of these, 318 patients were included in final analysis. Serum creatinine was measured on admission as well as 24, 48, and 72 hours thereafter with AKI defined as an increase in serum creatinine of 0.3 mg/dl or more. Cardiac magnetic resonance (CMR) scans were performed in the first week after infarction, with microvascular injury visualized by late gadolinium enhancement CMR defined as any region of hypoenhancement within the hyperenhanced area of infarction. Sixteen patients developed AKI. They showed significantly lower left ventricular ejection fraction (45[interquartile range 40-52]% vs. 54[47-59]%), larger infarct size (21[15-35]% vs. 12[7-22]%) of left ventricular myocardial mass, and more frequent microvascular injury (81 vs. 46%) than those free of AKI. Meaningfully, in multivariate analysis including all CMR data, microvascular injury was the sole independent predictor of AKI (odds ratio 6.74, 95% confidence interval of 1.49-30.43). Thus, among revascularized STEMI patients, the presence of microvascular injury assessed by CMR was independently associated with an increased risk of AKI. This suggests a potential pathophysiological link between cardiac microvascular disease and renal injury following STEMI.
Databáze: OpenAIRE
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