An Improved Synthesis of the Triethylene Glycol-Substituted 4-(N-Methyl-N-Boc-Amino)Styrylpyridine
| Autor: | Huiqiang Wei, Yiliang Li, Duan Yuqing, Yuan Zhu, Jia Jianhua, Wenbin Hou, Yu Jiang, Ning Hongxin |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | ACS Omega ACS Omega, Vol 5, Iss 31, Pp 19446-19452 (2020) |
| ISSN: | 2470-1343 |
| Popis: | An improved five-step synthesis of triethylene glycol-substituted 4-(N-methyl-N-Boc-amino)styrylpyridine (6) is described. Using cost-effective starting materials, the developed synthesis route was synthetic, efficient, and chromatographic purification-free. The key point of the work is the one-pot synthesis of tert-butyl methyl(4-vinylphenyl)carbamate through methylation and elimination in the NaH/THF system. The new synthesis route shows the potential to achieve scaled-up preparation of 6 in the future. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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