Next-Generation Influenza HA Immunogens and Adjuvants in Pursuit of a Broadly Protective Vaccine
| Autor: | Jarrod J. Mousa, Kaito Nagashima |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Influenza vaccine medicine.medical_treatment lcsh:QR1-502 Hemagglutinin (influenza) Hemagglutinin Glycoproteins Influenza Virus Review Antibodies Viral lcsh:Microbiology Virus Mice 03 medical and health sciences 0302 clinical medicine Adjuvants Immunologic Orthomyxoviridae Infections adjuvant Antibody Repertoire Antigen vaccine Virology Influenza Human medicine Animals Humans universal influenza vaccine antibodies Vaccines Virus-Like Particle hemagglutinin 030212 general & internal medicine Clinical Trials as Topic biology broadly neutralizing antibodies Immunity Humoral Vaccination 030104 developmental biology Infectious Diseases Influenza A virus Influenza Vaccines biology.protein Antibody influenza Adjuvant |
| Zdroj: | Viruses, Vol 13, Iss 546, p 546 (2021) Viruses |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v13040546 |
| Popis: | Influenza virus, a highly mutable respiratory pathogen, causes significant disease nearly every year. Current vaccines are designed to protect against circulating influenza strains of a given season. However, mismatches between vaccine strains and circulating strains, as well as inferior vaccine effectiveness in immunodeficient populations, represent major obstacles. In an effort to expand the breadth of protection elicited by influenza vaccination, one of the major surface glycoproteins, hemagglutinin (HA), has been modified to develop immunogens that display conserved regions from multiple viruses or elicit a highly polyclonal antibody response to broaden protection. These approaches, which target either the head or the stalk domain of HA, or both domains, have shown promise in recent preclinical and clinical studies. Furthermore, the role of adjuvants in bolstering the robustness of the humoral response has been studied, and their effects on the vaccine-elicited antibody repertoire are currently being investigated. This review will discuss the progress made in the universal influenza vaccine field with respect to influenza A viruses from the perspectives of both antigen and adjuvant, with a focus on the elicitation of broadly neutralizing antibodies. |
| Databáze: | OpenAIRE |
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