Apolipoprotein B gene haplotypes. Association between Ag and DNA polymorphisms
| Autor: | P O Kwiterovich, C Heinzman, Aldons J. Lusis, J A Ladias, R Bütler, Stylianos E. Antonarakis, Verne N. Schumaker, Y H Ma |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Linkage disequilibrium Apolipoprotein B Arteriosclerosis Genetic Linkage Biology Exon Epitopes Genotype Humans Allele Codon Deoxyribonucleases Type II Site-Specific Gene Triglycerides Apolipoproteins B Genetics Polymorphism Genetic Haplotype DNA Middle Aged Molecular biology Blotting Southern Cholesterol Phenotype Haplotypes biology.protein Female Restriction fragment length polymorphism Cardiology and Cardiovascular Medicine Polymorphism Restriction Fragment Length |
| Zdroj: | Arteriosclerosis (Dallas, Tex.). 8(5) |
| ISSN: | 0276-5047 |
| Popis: | Berg et al. (Clin Genet 1986;30:515-520) have reported that an Xba I DNA polymorphic site in exon 26 of the apolipoprotein (apo) B gene is associated both with the Ag(x/y) immunochemical polymorphism and with elevated serum lipoprotein levels. Ma et al. (Arteriosclerosis 1987;7:301-305) have reported that the same Xba I polymorphism is associated with a different immunochemical polymorphism, Ag(c/g). To extend and clarify these observations, we have determined the Ag and Xba I polymorphism for 106 individuals. We find that the Xba I restriction fragment length polymorphism is in linkage disequilibrium with both Ag(x/y) and Ag(c/g) loci; thus, all 31 Xba I(X1/X1) genotypes observed in this study are also Ag(y/y). All but one of 22 Xba I(X2/X2) genotypes are also Ag(g/g). For individuals homozygous at either two or three of these loci, it was possible to determine the haplotypes for 128 apo B alleles. Of the eight possible apo B haplotypes, only four were represented in this unambiguous subpopulation, although other minor haplotypes were present in the total population from which it was derived. The identification of major apo B haplotypes in human populations may simplify the search for significant correlations between certain apo B alleles and lipid levels and atherosclerosis. |
| Databáze: | OpenAIRE |
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