Clinical applications of the urokinase receptor (uPAR) for cancer patients
| Autor: | Peter J. K. Kuppen, F.J.G.M. Kubben, S. Ganesh, Hein W. Verspaget, Alexander L. Vahrmeijer, Martin C. Boonstra, Cornelis F. M. Sier, Cornelis J.H. van de Velde, Paul H.A. Quax |
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| Rok vydání: | 2011 |
| Předmět: |
Diagnostic Imaging
diagnosis Cell Antineoplastic Agents exosomes Receptors Urokinase Plasminogen Activator Neoplasms Drug Discovery medicine Biomarkers Tumor Malignant cells Humans Receptor targeting Pharmacology Urokinase therapy business.industry Urokinase Plasminogen Activator Cancer imaging Diagnostic marker medicine.disease Urokinase receptor Gene Expression Regulation Neoplastic medicine.anatomical_structure Immunology Cancer research prognosis business uPAR medicine.drug |
| Zdroj: | Current Pharmaceutical Design, 17(19), 1890-1910 |
| ISSN: | 1873-4286 |
| Popis: | Since decades the urokinase plasminogen activator (uPA) system has been associated with the invasion of malignant cells. The receptor of urokinase (uPAR) is one of the key players in this proteolytic cascade, because it focuses uPA's proteolytic activity to the cell surface and in addition functions as a signaling receptor. uPAR is highly expressed in virtually all human cancers, suggesting possible clinical applications as diagnostic marker, predictive tool of survival or clinical response, and as a target for therapy and imaging. This review summarizes the possibilities of uPAR in clinical applications for cancer patients. |
| Databáze: | OpenAIRE |
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