Effects of Ro 40–5967, a New Calcium Antagonist, and Enalapril on Cardiac Remodeling in Renal Hypertensive Rats
| Autor: | Murielle Véniant, Jean-Paul Clozel, Didier Heudes, Ludger Banken, Joël Ménard |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Hypertension Renal Tetrahydronaphthalenes Hemodynamics Renovascular hypertension Renin-Angiotensin System Enalapril Heart Rate Coronary Circulation medicine.artery Internal medicine Renin–angiotensin system medicine Animals Rats Wistar Renal artery Pharmacology biology business.industry Antagonist Heart Angiotensin-converting enzyme Organ Size Calcium Channel Blockers medicine.disease Rats Blood pressure Endocrinology Mibefradil biology.protein Benzimidazoles Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 21:544-551 |
| ISSN: | 0160-2446 |
| Popis: | The goal of the present study was to compare the effects of an angiotensin-converting enzyme (ACE) inhibitor (enalapril) and a long-acting calcium antagonist (Ro 40-5967) on cardiac remodeling secondary to renovascular hypertension. For this purpose, two kidney-one clip (2K-1C) hypertensive rats, 6 weeks after renal artery clipping, were either untreated or treated for 5 weeks with equihypotensive doses of enalapril (3 mg/kg/day) and Ro 40-5967 (30 mg/kg/day). At the end of the treatment period, cardiac weight, maximum coronary blood flow ([MCBF], measured in isolated perfused hearts), and interstitial and perivascular collagen volume fraction (measured by morphometry) were evaluated in all rats. Both drugs similarly decreased arterial blood pressure (ABP) for 24 h. Enalapril was more effective than Ro 40-5967 in inducing regression of cardiac hypertrophy. MCBF was decreased in untreated hypertensive rats and was increased to the same extent by both treatments, although not normalized. Interstitial cardiac collagen content after 11 weeks of hypertension was not increased in untreated hypertensive rats. In contrast, the collagen volume fraction measured in the perivascular area was increased in untreated hypertensive rats and this increase was not significantly suppressed by either enalapril or Ro 40-5967. These results show that cardiac hypertrophy, decrease in MCBF and increase in myocardial collagen content, do not evolve in parallel in 2K-1C hypertensive rats. Two antihypertensive treatments, enalapril and Ro 40-5967, increased MCBF to the same extent but had different effects on cardiac hypertrophy despite having equal antihypertensive efficacy. |
| Databáze: | OpenAIRE |
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