The effects of two iso-volume endurance training protocols on mitochondrial dysfunction in type 2 diabetic male mice
| Autor: | Mohammad Reza Sadeghian Shahi, Mehrdad Fathei, Mohammad Mosaferi Ziaaldini, Seyed Reza Attarzadeh Hosseini, Masoumeh Sadat Modaresi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes 03 medical and health sciences 0302 clinical medicine Endurance training Internal medicine Diabetes mellitus Internal Medicine medicine Citrate synthase Cytochrome c oxidase Treadmill biology business.industry TFAM Streptozotocin medicine.disease 030104 developmental biology Endocrinology biology.protein business medicine.drug Research Article |
| Zdroj: | J Diabetes Metab Disord |
| Popis: | PURPOSE: Type 2diabetes(T2D) is one of the more common diseases in the world and has been widely spread. One of the suggested mechanisms in development of T2D, is mitochondrial dysfunction. The purpose of this study is to compare the effects of two endurance training protocols with low and moderate intensity on biogenesis and mitochondrial function, in Diabetic mice induced by high fat diet and Streptozotocin(STZ). METHODS: 40 five week old mice divided to four groups including: health control (HC, n = 7), diabetic control (DC, n = 7), low endurance training (DLT, n = 7) and moderate endurance training (DMT, n = 7). DMT group ran at 5 m/min for an hour, 3 days a week on a treadmill, and DLT group ran at 3 m/min for an hour, 5 days a week on a treadmill for 8 weeks. RESULTS: The cytosolic content of PGC1α, Tfam and mitochondrial content of citrate synthase(Cs) and cytochrome c oxidase(Cox) in DC was significantly reduced compared to HC(P˂0.05). All of the parameters except for Cs in both DLT and DMT were increased compared to DC (P˂0.05), but there was no difference between them and the HC (P˃0.05). There was no difference in Cs enzyme between the DC and the DLT(P˃0.05), but it was significantly increased in the DMT(P˂0.05). There was a significantly difference between Cs enzyme in HC and DLT(P˂0.05), but there wasn’t any significant difference between HC and DMT(P˃0.05). CONCLUSIONS: The results showed that in same volume condition, both endurance training protocols improved the proteins involved in biogenesis and mitochondrial function in T2D mice and there was no significant difference between them. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|