Omega-3 fatty acids reduce lipopolysaccharide-induced abnormalities in expression of connexin-40 in aorta of hereditary hypertriglyceridemic rats
| Autor: | Ľ Okruhlicová, Jana Navarová, Jan Slezak, Ruzena Sotnikova, Branislav Kura, J KriŽák, Iveta Bernatova, Zora Haviarová, K. Frimmel |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Vascular wall Lipopolysaccharides Male medicine.medical_specialty Lipopolysaccharide Physiology Blotting Western Connexin Antigens Differentiation Myelomonocytic 030204 cardiovascular system & hematology Connexins 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Antigen Antigens CD Internal medicine medicine.artery Fatty Acids Omega-3 medicine Animals Aorta Hypertriglyceridemia Gap junction protein General Medicine medicine.disease Rats Blot 030104 developmental biology Endocrinology chemistry |
| Zdroj: | ResearcherID Scopus-Elsevier |
| ISSN: | 1802-9973 |
| Popis: | Omega-3 fatty acids (omega3FA) are known to reduce hypertriglyceridemia- and inflammation-induced vascular wall diseases. However, mechanisms of their effects are not completely clear. We examined, whether 10-day omega3FA diet can reduce bacterial lipopolysaccharide-induced changes in expression of gap junction protein connexin40 (Cx40) in the aorta of hereditary hypertriglyceridemic (hHTG) rats. After administration of a single dose of lipopolysaccharide (LPS, 1 mg/kg, i.p.) to adult hHTG rats, animals were fed with omega3FA diet (30 mg/kg/day) for 10 days. LPS decreased Cx40 expression that was associated with reduced acetylcholine-induced relaxation of aorta. Omega3FA administration to LPS rats had partial anti-inflammatory effects, associated with increased Cx40 expression and improved endothelium dependent relaxation of the aorta. Our results suggest that 10-day omega3FA diet could protect endothelium-dependent relaxation of the aorta of hHTG rats against LPS-induced damage through the modulation of endothelial Cx40 expression. |
| Databáze: | OpenAIRE |
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