Paraneoplastic opsoclonus myoclonus syndrome associated with inflammatory myofibroblastic tumor in a pediatric patient
| Autor: | Jefree J. Schulte, Susan L. Cohn, Amir Siddiqui, Karyn Gerstle |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pathology medicine.medical_specialty Article Neoplasms Muscle Tissue 03 medical and health sciences 0302 clinical medicine Autoimmune Process Adrenal Cortex Hormones hemic and lymphatic diseases Neuroblastoma Antineoplastic Combined Chemotherapy Protocols Opsoclonus myoclonus syndrome medicine Humans Anaplastic lymphoma kinase Opsoclonus-Myoclonus Syndrome business.industry Immunoglobulins Intravenous Gamma globulin Hematology medicine.disease Neuroblastic Tumor Pediatric patient Oncology Child Preschool 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Rituximab business Immunosuppressive Agents Follow-Up Studies 030215 immunology medicine.drug |
| Zdroj: | Pediatr Blood Cancer |
| ISSN: | 1545-5017 1545-5009 |
| Popis: | Opsoclonus myoclonus syndrome (OMS) is a rare neurological syndrome caused by a paraneoplastic autoimmune process that affects children with neuroblastic tumors. Treatment includes corticosteroids, intravenous gamma globulin (IVIG), rituximab, and other immunosuppressive therapies. Here, we describe a patient diagnosed with OMS associated with a localized inflammatory myofibroblastic tumor. The patient has no evidence of tumor recurrence following surgical resection with 8-month follow-up. The neurologic symptoms resolved with corticosteroids and IVIG. This case demonstrates that in children, neoplasms other than neuroblastoma may be associated with this paraneoplastic syndrome, and highlights the importance of evaluating patients with OMS for underlying malignancies. |
| Databáze: | OpenAIRE |
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