MODULATION OF BILE ACIDS INDUCED BY PARAQUAT IN RABBITS
| Autor: | M.S.I. Dhami, Ali M, Al-Sweedan N, M. Menon, Fareed A, Mohammed N, M. Afzal |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Paraquat Vitamin medicine.medical_specialty Taurine Bilirubin medicine.medical_treatment Glycine Chenodeoxycholic Acid Bile Acids and Salts Diffusion chemistry.chemical_compound Chenodeoxycholic acid Internal medicine medicine Animals Pharmacology (medical) Chromatography High Pressure Liquid Phospholipids Herbicides Vitamin E Deoxycholic acid Cholic acid Diet Endocrinology chemistry Biochemistry Carbohydrate Metabolism Spectrophotometry Ultraviolet Rabbits |
| Zdroj: | Drug Metabolism and Drug Interactions. 11 |
| ISSN: | 2191-0162 0792-5077 |
| DOI: | 10.1515/dmdi.1994.11.4.301 |
| Popis: | Rabbit bile was examined for changes in composition induced by paraquat. Paraquat was administered intraperitoneally and changes in bile components were monitored by high performance liquid chromatography. Alterations in the ratios of total glycine/taurine conjugated bile acids (TGC/TTC), cholic acid/deoxycholic acid (CA/DC), cholic acid/chenodeoxycholic acid (CA/CDC) and cholic acid/cholesterol (CA/CH) were measured as an index of paraquat toxicity. A statistically significant increase in the ratio of TGC/TTC was observed, while CA/DC, CA/CDC and CA/CH showed a decrease. Phospholipids, protein, sugar, bilirubin, beta-carotene, vitamin A and vitamin E in the bile and serum of the experimental animals were also monitored. In bile, the levels of cholesterol, phospholipids, protein, sugar, and total bile acids increased while the levels of the antioxidants beta-carotene, vitamin A and vitamin E decreased. A decrease in the bilirubin content of the bile was also observed. These modifications may be useful clinically for assessment of paraquat toxicity. |
| Databáze: | OpenAIRE |
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