The RNAz web server: prediction of thermodynamically stable and evolutionarily conserved RNA structures
| Autor: | Andreas Gruber, Stefan Washietl, Richard Neuböck, Ivo L. Hofacker |
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| Rok vydání: | 2007 |
| Předmět: |
Web server
Molecular Sequence Data education Sequence alignment Computational biology Regulatory Sequences Ribonucleic Acid Biology computer.software_genre Genome Conserved sequence Evolution Molecular Genetics Gene Conserved Sequence Internet Base Sequence Sequence Analysis RNA Computational Biology RNA Articles Non-coding RNA Pipeline (software) ComputingMethodologies_PATTERNRECOGNITION Nucleic Acid Conformation Thermodynamics Sequence Alignment computer Algorithms Software |
| Zdroj: | University of Vienna-u:cris Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| DOI: | 10.1093/nar/gkm222 |
| Popis: | Many non-coding RNA genes and cis-acting regulatory elements of mRNAs contain RNA secondary structures that are critical for their function. Such functional RNAs can be predicted on the basis of thermodynamic stability and evolutionary conservation. We present a web server that uses the RNAz algorithm to detect functional RNA structures in multiple alignments of nucleotide sequences. The server provides access to a complete and fully automatic analysis pipeline that allows not only to analyze single alignments in a variety of formats, but also to conduct complex screens of large genomic regions. Results are presented on a website that is illustrated by various structure representations and can be downloaded for local view. The web server is available at: rna.tbi.univie.ac.at/RNAz. |
| Databáze: | OpenAIRE |
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