Abnormal expression of the MOS proto-oncogene in human thyroid medullary carcinoma
| Autor: | B. M. Stringer, J. M. Seid, S. Ingemansson, N. Woodhouse, M. H. Goyns, M. H. Parkar |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
endocrine system
Cancer Research Pathology medicine.medical_specialty Retroviridae Proteins Oncogene Proteins v-mos Biology Proto-Oncogene Mas Proto-Oncogenes Gene expression medicine Humans RNA Messenger Thyroid Neoplasms Northern blot Gene Southern blot Messenger RNA Oncogene Carcinoma Thyroid Blotting Northern medicine.disease Molecular biology Blotting Southern medicine.anatomical_structure Oncology Medullary carcinoma |
| Zdroj: | Cancer Letters. 43:185-189 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/0304-3835(88)90169-3 |
| Popis: | We have been studying the expression of a range of proto-oncogenes in human thyroid tumour tissue by using Northern blot analysis. We have demonstrated the expression of a MOS mRNA of 1 kb in all thyroid samples. Furthermore, in a medullary carcinoma sample we also observed additional mRNA species of 1.7 and 2.2 kb. Southern blot analysis of DNA prepared from the same tumour sample did not reveal a rearrangement of the gene. These findings are the first report of MOS expression in any human tissue, and indicate that MOS oncogene activation might be important in the development of some thyroid tumours. |
| Databáze: | OpenAIRE |
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