IQGAP1 and its binding proteins control diverse biological functions
| Autor: | David B. Sacks, Huseyin H. Erdemir, Colin D. White |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Scaffold protein
Proto-Oncogene Proteins c-akt Plasma protein binding Biology Microtubules DNA-binding protein Article Mice Phosphatidylinositol 3-Kinases IQGAP1 Cell Movement Protein Interaction Mapping Animals Humans Small GTPase Phosphorylation Cytoskeleton Mitogen-Activated Protein Kinase Kinases Nuclear Proteins Receptor Protein-Tyrosine Kinases Adherens Junctions Cell Biology Actins Cell biology Transport protein Protein Transport Gene Expression Regulation ras GTPase-Activating Proteins Receptors Chemokine Signal transduction Carrier Proteins Protein Binding Signal Transduction |
| Zdroj: | Cellular Signalling. 24:826-834 |
| ISSN: | 0898-6568 |
| DOI: | 10.1016/j.cellsig.2011.12.005 |
| Popis: | IQGAP proteins have been identified in a wide spectrum of organisms, ranging from yeast to humans. The most extensively studied family member is the ubiquitously expressed scaffold protein IQGAP1, which participates in multiple essential aspects of mammalian biology. IQGAP1 mediates these effects by binding to and regulating the function of numerous interacting proteins. Over ninety proteins have been reported to associate with IQGAP1, either directly or as part of a larger complex. In this review, we summarise those IQGAP1 binding partners that have been identified in the last five years. The molecular mechanisms by which these interactions contribute to the functions of receptors and their signalling cascades, small GTPase function, cytoskeletal dynamics, neuronal regulation and intracellular trafficking are evaluated. The evidence that has accumulated recently validates the role of IQGAP1 as a scaffold protein and expands the repertoire of cellular activities in which it participates. |
| Databáze: | OpenAIRE |
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