Vulnerability of the developing airway
| Autor: | Abhrajit Ganguly, Richard J. Martin |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult medicine.medical_specialty Physiology Population Respiratory System Lung injury Article 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Parenchyma Medicine Humans education Bronchopulmonary Dysplasia Respiratory Sounds Hyperoxia education.field_of_study business.industry General Neuroscience Infant Newborn Infant respiratory system medicine.disease Respiration Disorders Airway hyperreactivity Asthma respiratory tract diseases 030228 respiratory system Bronchopulmonary dysplasia Dilator Cardiology Female medicine.symptom business Airway 030217 neurology & neurosurgery Infant Premature |
| Zdroj: | Respir Physiol Neurobiol |
| ISSN: | 1878-1519 |
| Popis: | Longer term respiratory morbidity is a frequent concern for former preterm infants. Increased airway reactivity and wheezing disorders are extremely common in this population, both in infants who meet diagnostic criteria for bronchopulmonary dysplasia [BPD], and in the absence of this diagnosis. It is, therefore, imperative to gain a better understanding of normal and abnormal postnatal development of the immature airway. Airway hyperreactivity may be secondary to abnormal bronchoalveolar attachments in the face of parenchymal lung injury, or secondary to an imbalance between constrictor and dilator neural pathways. Finally, the airway itself may undergo functional and/or structural changes, including increased airway smooth muscle mass, and changes in airway extracellular matrix which may, in turn, modulate downstream signaling pathways to hyperoxia or pressure exposed vulnerable airways. |
| Databáze: | OpenAIRE |
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