Characterization and Significance of Collagen Induced Biphasic Aggregation of Human Platelets
| Autor: | Chung‐hsin Ts'ao |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Epinephrine Platelet Aggregation Platelet aggregation Smoking habit Coronary Disease Stimulation Elevated serum chemistry.chemical_compound Internal medicine Diabetes mellitus medicine Humans Platelet Aged Hematology Middle Aged medicine.disease Stimulation Chemical Blood Cell Count Adenosine Diphosphate Cerebrovascular Disorders Adenosine diphosphate Endocrinology chemistry Biochemistry Female Collagen medicine.drug |
| Zdroj: | Scandinavian Journal of Haematology. 15:171-177 |
| ISSN: | 0036-553X |
| DOI: | 10.1111/j.1600-0609.1975.tb01071.x |
| Popis: | Biphasic collagen-induced platelet aggregation, resembling that induced by epinephrine, was noted in platelet-rich plasma (PRP) of 11 stroke and 1 coronary disease patients. Similar pattern of aggregation was not observed in normal PRP. The occurrence of the biphasic collagen aggregation does not appear to relate to platelet count, smoking habit, medication, or other abnormalities such as hypertension, diabetes, and elevated serum lipid levels. However, platelets of these patients were very sensitive to aggregating agents including epinephrine and adenosine diphosphate. The concentration of collagen that elicited biphasic aggregation in these platelets was too weak to aggregate platelets of normal subjects. We believe that the release threshold of these platelets is reduced to such an extent that minute amounts of collagen, which would be insufficient to induce release from normal platelets, are capable of inducing release from these platelets. Both phases of collagen induced aggregation are probably resulted from the activation of the release mechanism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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