What We Need to Know about Solid-State Isothermal Crystallization of Organic Molecules from the Amorphous State below the Glass Transition Temperature
| Autor: | Ann Newman, George Zografi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Solid-state Pharmaceutical Science Thermodynamics 02 engineering and technology Molecular Dynamics Simulation 030226 pharmacology & pharmacy Organic molecules 03 medical and health sciences 0302 clinical medicine X-Ray Diffraction Drug Discovery Transition Temperature Supercooling Calorimetry Differential Scanning technology industry and agriculture Isothermal crystallization State (functional analysis) 021001 nanoscience & nanotechnology Amorphous solid Kinetics Molecular Medicine Physical stability Glass 0210 nano-technology Glass transition Crystallization |
| Zdroj: | Molecular pharmaceutics. 17(6) |
| ISSN: | 1543-8392 |
| Popis: | In this Perspective, the authors have examined various principles associated with the isothermal crystallization of organic molecules from the amorphous state. The major objective was to better understand the underlying principles influencing long-term crystallization from the glassy state at temperatures sufficiently low enough to prevent crystallization over a period of about 2-3 years; this time frame was chosen based on the requirements for ensuring the physical stability of solid drug products. As such, after considering the general thermodynamic, dynamic (molecular mobility), and structural properties of both supercooled liquids and glasses, current understanding from the literature of overall crystallization, nucleation and growth from glasses, was reviewed. Typically, in attempting to establish the appropriate storage temperature |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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