Maternal Metabolic Complications in Pregnancy and Offspring Behavior Problems at 2 Years of Age

Autor: Piush J. Mandhane, Jacqueline Pei, Anita L. Kozyrskyj, Allan B. Becker, John E Krzeczkowski, Ryan J. Van Lieshout, Russell J. de Souza, Padmaja Subbarao, Diana L. Lefebvre, Lisa Smithson, Jennifer Fitzpatrick, Amanda Lau, Louis A. Schmidt, Child Study Investigators, Stuart E. Turvey, Malcolm R. Sears, Sukhpreet K Tamana
Rok vydání: 2019
Předmět:
Adult
Blood Glucose
Male
Postpartum depression
Canada
medicine.medical_specialty
Epidemiology
Offspring
Child Behavior
Child Behavior Disorders
Body Mass Index
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Pregnancy
Risk Factors
030225 pediatrics
medicine
Humans
Longitudinal Studies
Obesity
Child
Child Behavior Checklist
Adiposity
Problem Behavior
2. Zero hunger
030219 obstetrics & reproductive medicine
Prenatal nutrition
Psychopathology
Obstetrics
business.industry
Mental Disorders
Confounding
Public Health
Environmental and Occupational Health
Infant
Obstetrics and Gynecology
medicine.disease
Checklist
3. Good health
Gestational diabetes
Diabetes
Gestational
Child
Preschool
Prenatal Exposure Delayed Effects
Pediatrics
Perinatology and Child Health
Female
business
Body mass index
Zdroj: Maternal and Child Health Journal. 23:746-755
ISSN: 1573-6628
1092-7875
DOI: 10.1007/s10995-018-2691-y
Popis: Objectives Prenatal maternal metabolic problems such as pre-pregnancy adiposity, excess gestational weight gain, and gestational diabetes mellitus (GDM) are associated with an increased risk of psychopathology in offspring. We examined whether these exposures were linked to symptoms of emotional and behavioral problems in offspring at 2 years of age, or if associations were due to confounding variables. Methods Data from 815 mother–child pairs enrolled at the Edmonton site of the Canadian Healthy Infant Longitudinal Development cohort were used to examine associations between gestational metabolic complications and scores on the externalizing and internalizing scales of the Child Behavior Checklist (CBCL-1½ to 5) at age two. Associations between maternal metabolic complications and offspring psychopathology were assessed before and after adjustment for gestational diet, socioeconomic status (SES), postpartum depression (PPD), prenatal smoking and breastfeeding. Results Pre-pregnancy body mass index and GDM, but not gestational weight gain, predicted more offspring externalizing and internalizing problems. However, after adjustment for confounding variables, these associations were no longer statistically significant. Post-hoc analyses revealed that gestational diet accounted for unique variance in both externalizing (semi-partial rdiet = − 0.20, p
Databáze: OpenAIRE
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