EGFR mutation in non-small cell lung cancer(NSCLC) in South Croatia
| Autor: | Veljka Ivčević, Sendi Kuret, Ivan Škopljanac, Meri Glavina Durdov, Suzana Mladinov, Kornelija Miše |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Mutation medicine.medical_specialty education.field_of_study Lung medicine.diagnostic_test business.industry Population non-small cell lung cancer (NSCLC) medicine.disease medicine.disease_cause Metastasis Exon medicine.anatomical_structure Internal medicine Biopsy medicine Carcinoma EGFR mutation education business |
| Zdroj: | 11.1 Lung Cancer. |
| DOI: | 10.1183/13993003.congress-2015.pa4249 |
| Popis: | Introduction: NSCLC accounts for about 85% of lung cancers and includes predominantly adenocarcinomas. An important part of treatment are targeted therapies based on genetic alterations in the tumor. EGFR mutations are different in different ethnic groups, 30-40% in Asians, but in Caucasians only 10-15%. Aim and Objectives: To determine the percentage of EGFR positive mutations in non-small cell lung carcinomas of the population of South-Croatian region Dalmatia and compare the data with other studies. Methods: Specimens are obtained by biopsy of lung tumors with fiber bronchoscopy, trans-thoracic biopsy or surgery. Testing was done with real-time PCR method for quantitative identification of mutations in exons 18,19,20 and 21 of EGFR gene. Results: Of the 218 tested patients, 204 had adenocarcinoma,10 squamous cell carcinoma, 2 microcellular carcinoma and 2 had metastases in lungs . There were 142 men and 76 women. Regarding only NSC-lung carcinomas 15 patients (7.0%) showed a mutation of EGFR gene. In total number of women, 10 had positive EGFR-mutation (13.1%) which accounts for 66% of all noted mutations. Among tested materials there was one EGFR-positive metastasis originating from colon adenocarcinoma. Conclusion: In our population we found similar results compared to the study in Central Europe that showed prevalence of 4.9% EGFR-positive mutations among 552 analysed patiens and 8.5% among female patients.(Boch et al.2013.) Some European studies report from 10 to 27% EGFR-positive mutations. (Khambata-Ford et al. 2010, Zandwijk et al. 2006, Hirsch et al 2007). |
| Databáze: | OpenAIRE |
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