delta-Aminolevulinic acid dehydratase enzyme activity in blood, brain, and liver of lead-dosed ducks
| Autor: | Michael P. Dieter, Mack T. Finley |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Cerebellum Erythrocytes Fowl Central nervous system Biochemistry Internal medicine medicine Animals Butyrylcholinesterase General Environmental Science biology Brain Porphobilinogen Synthase biology.organism_classification Enzyme assay Endocrinology medicine.anatomical_structure Ducks nervous system Lead Liver Dehydratase Toxicity biology.protein Delta-aminolevulinic acid dehydratase Acetylcholinesterase |
| Zdroj: | Environmental research. 19(1) |
| ISSN: | 0013-9351 |
| Popis: | Mallard ducks were dosed with a single shotgun pellet (ca. 200 mg lead). After 1 month there was about 1 ppm lead in blood, 2.5 in liver, and 0.5 in brain. Lead-induced inhibition of δ-aminolevulinic acid dehydratase enzyme in blood and cerebellum was much greater than in cerebral hemisphere or liver and was strongly correlated with the lead concentration in these tissues. The cerebellar portion of the brain was more sensitive to δ-aminolevulinic acid dehydratase enzyme inhibition by lead than were the other tissues examined. There was also a greater increase in the glial cell marker enzyme, butyrylcholinesterase, in cerebellum than in cerebral hemisphere, suggesting that nonregenerating neuronal cells were destroyed by lead and replaced by glial cells in that portion of the brain. Even partial loss of cerebellar tissue is severely debilitating in waterfowl, because functions critical to survival such as visual, auditory, motor, and reflex responses are integrated at this brain center. |
| Databáze: | OpenAIRE |
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