High Serum Apolipoprotein E Determines Hypertriglyceridemic Dyslipidemias, Coronary Disease and ApoA-I Dysfunctionality
| Autor: | Günay Can, Erkan Ayhan, Nihan Erginel-Unaltuna, Ender Örnek, Altan Onat, Sani Namik Murat |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Apolipoprotein E medicine.medical_specialty Waist Apolipoprotein B Clinical chemistry Population Coronary Disease Biochemistry Apolipoproteins E Internal medicine medicine Humans Prospective Studies education Aged Apolipoproteins B Dyslipidemias Hypertriglyceridemia Metabolic Syndrome education.field_of_study Apolipoprotein A-I biology business.industry Organic Chemistry nutritional and metabolic diseases Cell Biology Middle Aged medicine.disease C-Reactive Protein Cross-Sectional Studies Endocrinology Homeostatic model assessment biology.protein Female lipids (amino acids peptides and proteins) business Lipidology |
| Zdroj: | Lipids. 48:51-61 |
| ISSN: | 1558-9307 0024-4201 |
| DOI: | 10.1007/s11745-012-3724-8 |
| Popis: | The relevance of serum apolipoprotein E (apoE) levels to two hypertriglyceridemic dyslipidemias has not been clarified. We explored, in a cross-sectional (and short-term prospective) evaluation, the independent relationship of serum apoE to the atherogenic dyslipidemia, hypertriglyceridemia with elevated apoB (HtgB) and to apoA-I dysfunctionality, previously shown in Turkish adults to be independent of apoE genotype. Serum apoE concentrations were measured by immunonephelometry in 1,127 middle-aged adults. In multivariable regression analysis, apoE concentrations showed log-linear associations with apoB and apoA-I levels, waist circumference, independent of C-reactive protein (CRP), homeostatic model assessment (HOMA) index and other confounders. The likelihood of atherogenic dyslipidemia and of HtgB roughly tripled per 1-SD increment in apoE concentrations, additively to apoE genotype, HOMA, apoA-I, CRP concentrations and waist circumference; yet apoA-I, protective against atherogenic dyslipidemia, appeared to promote HtgB, a finding consistent with apoA-I dysfunctionality in this setting. Each 1-SD increment in the apoE level was moreover, associated in both genders with MetS (at OR 1.5), after adjustment for sex, age, apoB, apoA-I and CRP, or for apoE genotypes. Circulating apoE predicted in both genders age-adjusted prevalent and incident coronary heart disease (CHD), independent of apoE genotype and CRP (OR 1.32 [95 % CI 1.11; 1.58]). To conclude, in a general population prone to MetS, elevated apoE concentrations are strongly linked to HtgB and atherogenic dyslipidemia, irrespective of apoE genotype, are associated with MetS and CHD. Excess apoE reflects pro-inflammatory state and likely autoimmune activation. |
| Databáze: | OpenAIRE |
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