Exploring the Role of Fallopian Ciliated Cells in the Pathogenesis of High-Grade Serous Ovarian Cancer

Autor: Laura Cesaratto, Gian Luca Rampioni Vinciguerra, Emanuela Gardenal, Riccardo Bianchet, Riccardo Spizzo, Milena S. Nicoloso, Michela Coan, Erik Dassi, Andrea Vecchione, Gustavo Baldassarre
Rok vydání: 2018
Předmět:
0301 basic medicine
epithelial ovarian cancer
ciliated cells
medicine.medical_treatment
Tumor initiation
Review
Carcinoma
Ovarian Epithelial
LRP2BP
SPAG6
Pathogenesis
lcsh:Chemistry
DNAAF1
Medicine
molecular biology
C20orf85
Family history
lcsh:QH301-705.5
media_common
Ovarian Neoplasms
STK33
General Medicine
inorganic chemistry
3. Good health
Computer Science Applications
Serous fluid
medicine.anatomical_structure
Neoplastic Stem Cells
Female
Disease Susceptibility
spectroscopy
media_common.quotation_subject
MARCH10
computer science applications1707 computer vision and pattern recognition
03 medical and health sciences
CCDC170
LRRC46
predisposition
RSPH10B2
TPPP
catalysis
physical and theoretical chemistry
organic chemistry
Animals
Humans
Genetic Predisposition to Disease
Ovulation
Fallopian Tubes
Chemotherapy
Mucous Membrane
business.industry
Genetic Variation
Oncogenes
Follicular fluid
Cystadenocarcinoma
Serous
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Cancer research
Neoplasm Grading
business
Biomarkers
Fallopian tube
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 9, p 2512 (2018)
ISSN: 1422-0067
Popis: High-grade serous epithelial ovarian cancer (HGSOC) is the fifth leading cause of cancer death in women and the first among gynecological malignancies. Despite an initial response to standard chemotherapy, most HGSOC patients relapse. To improve treatment options, we must continue investigating tumor biology. Tumor characteristics (e.g., risk factors and epidemiology) are valuable clues to accomplish this task. The two most frequent risk factors for HGSOC are the lifetime number of ovulations, which is associated with increased oxidative stress in the pelvic area caused by ovulation fluid, and a positive family history due to genetic factors. In the attempt to identify novel genetic factors (i.e., genes) associated with HGSOC, we observed that several genes in linkage with HGSOC are expressed in the ciliated cells of the fallopian tube. This finding made us hypothesize that ciliated cells, despite not being the cell of origin for HGSOC, may take part in HGSOC tumor initiation. Specifically, malfunction of the ciliary beat impairs the laminar fluid flow above the fallopian tube epithelia, thus likely reducing the clearance of oxidative stress caused by follicular fluid. Herein, we review the up-to-date findings dealing with HGSOC predisposition with the hypothesis that fallopian ciliated cells take part in HGSOC onset. Finally, we review the up-to-date literature concerning genes that are located in genomic loci associated with epithelial ovarian cancer (EOC) predisposition that are expressed by the fallopian ciliated cells.
Databáze: OpenAIRE
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