Early chemotherapy for non-tuberculous mycobacterial infections in patients with cystic fibrosis
| Autor: | U Forslöw, Lena Hjelte, Björn Petrini, Nadja Heurlin, A Geborek |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancreatic disease Adolescent Cystic Fibrosis medicine.drug_class medicine.medical_treatment Antibiotics Antitubercular Agents Mycobacterium Infections Nontuberculous Antimycobacterial Cystic fibrosis Cohort Studies Pharmacotherapy Internal medicine Clarithromycin medicine Humans Child Amikacin Mycobacterium avium-intracellulare Infection Retrospective Studies Chemotherapy business.industry Respiratory disease General Medicine bacterial infections and mycoses medicine.disease Mycobacterium avium Complex Anti-Bacterial Agents Pediatrics Perinatology and Child Health Immunology Mycobacterium kansasii Streptomycin Sputum Female medicine.symptom Rifampin business Ethambutol |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 92(8) |
| ISSN: | 0803-5253 |
| Popis: | Aim: To evaluate the response rate to antimycobacterial drug therapy in patients with cystic fibrosis (CF) suffering from infection by non-tuberculous mycobacteria (NTM). Methods: Ten patients, aged 10–34 y, out of 180 CF patients, were diagnosed with NTM disease. They had been regularly checked and examined for pulmonary symptoms, and had had chest X-rays and sputum cultures (including for mycobacteria) performed. One additional 36-y-old female received her CF diagnosis soon after the NTM diagnosis. Results: Mycobacterium avium-intracellulare complex (MAC) was found in 10 out of 11 patients and M. kansasii in 1 patient. Treatment with antimycobacterial drugs resulted in clinical improvement (weight gain or stabilization of weight and/or improved or stabilized lung function in 8 out of 11 patients) and mycobacterial culture turned negative in 10 out of 11. Conclusion: Promising results may be associated with early intervention with antimycobacterial therapy in CF patients. |
| Databáze: | OpenAIRE |
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