Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation
| Autor: | Yohan Lee, Jiyoung Park, Hyung Won Ryu, Mi Hyeon Park, Sun Sil Choi, Jang Hyun Choi, Jae Min Lee, Hyunduk Jang, Sei-Ryang Oh, Keon Woo Khim |
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| Rok vydání: | 2020 |
| Předmět: |
AMPK
0301 basic medicine medicine.medical_specialty medicine.drug_class Broussonetia papyrifera root bark Adipose tissue lcsh:TX341-641 Inflammation adipocyte Article Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Adipocyte Internal medicine medicine insulin sensitivity Protein kinase A broussonetia papyrifera root bark Nutrition and Dietetics medicine.disease 030104 developmental biology Endocrinology chemistry inflammation 030220 oncology & carcinogenesis Phosphorylation medicine.symptom lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Nutrients, Vol 12, Iss 3, p 773 (2020) Volume 12 Issue 3 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12030773 |
| Popis: | The chronic low-grade inflammation in adipose tissue plays a causal role in obesity-induced insulin resistance and its associated pathophysiological consequences. In this study, we investigated the effects of extracts of Broussonetia papyrifera root bark (PRE) and its bioactive components on inflammation and insulin sensitivity. PRE inhibited TNF-&alpha induced NF-&kappa B transcriptional activity in the NF-&kappa B luciferase assay and pro-inflammatory genes&rsquo expression by blocking phosphorylation of I&kappa B and NF-&kappa B in 3T3-L1 adipocytes, which were mediated by activating AMPK. Ten-week-high fat diet (HFD)-fed C57BL6 male mice treated with PRE had improved glucose intolerance and decreased inflammation in adipose tissue, as indicated by reductions in NF-&kappa B phosphorylation and pro-inflammatory genes&rsquo expression. Furthermore, PRE activated AMP-activated protein kinase (AMPK) and reduced lipogenic genes&rsquo expression in both adipose tissue and liver. Finally, we identified broussoflavonol B (BF) and kazinol J (KJ) as bioactive constituents to suppress pro-inflammatory responses via activating AMPK in 3T3-L1 adipocytes. Taken together, these results indicate the therapeutic potential of PRE, especially BF or KJ, in metabolic diseases such as obesity and type 2 diabetes. |
| Databáze: | OpenAIRE |
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