Nandrolone decanoate added to tamoxifen in the treatment of advanced breast cancer
| Autor: | Pentti Gröhn, Erkki Heinonen, Pentti Rissanen, Arto Alanko |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Cancer Research
medicine.medical_specialty Combination therapy Nausea Urology Breast Neoplasms law.invention Breast cancer Randomized controlled trial law Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Nandrolone skin and connective tissue diseases Aged business.industry Virilization Cancer Middle Aged medicine.disease Clinical trial Tamoxifen Endocrinology Receptors Estrogen Oncology Nandrolone Decanoate Female medicine.symptom Receptors Progesterone business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Breast Cancer Research and Treatment. 5:75-80 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/bf01807653 |
| Popis: | Since 1980 we have been carrying out a prospective randomized trial comparing tamoxifen with the combination of tamoxifen plus nandrolone decanoate in advanced breast cancer. The tamoxifen dose is 30 mg daily and the nandrolone decanoate dose 100 mg i.m. once a week for four weeks and thereafter every other week. 98 post-menopausal patients have been evaluated for the response. The number of patients is 49 in both groups. The overall response rates (CR + PR) to tamoxifen and tamoxifen plus nandrolone decanoate were not significantly different; in the tamoxifen group the response rate was 49% and in the combination group 45%. The mean time to progression in tamoxifen group is over 13 months and in tamoxifen plus nandrolone decanoate group over 12 months. Our results do not suggest a synergistic effect from combining tamoxifen and nandrolone decanoate treatments. The response rates to tamoxifen at different sites of metastases were as follows: bones 47%, soft tissues 56%, and viscera 48%. The respective figures with the combination therapy were 36%, 64%, and 40%. Both treatments were well tolerated and in no patient was withdrawal of the therapy necessary. Mild virilization and hoarseness were experienced by all patients treated with nandrolone decanoate. Side-effects associated with tamoxifen were rare, although five patients experienced nausea and two had hot flushes. |
| Databáze: | OpenAIRE |
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