Effect of maternal diabetes on phosphorylation of insulin-like growth factor binding protein-1 in cord serum
| Autor: | Mikko Loukovaara, E Nurminen, Kari Teramo, Pekka Leinonen, Eeva-Marja Rutanen, Sture Andersson |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism Birth weight Pregnancy in Diabetics Pregnancy Proteins Umbilical cord Insulin-like growth factor-binding protein Immunoenzyme Techniques Endocrinology Pregnancy Internal medicine Diabetes mellitus Internal Medicine medicine Birth Weight Humans Protein Isoforms Phosphorylation Type 1 diabetes Fetus biology business.industry Fetal Blood medicine.disease Insulin-Like Growth Factor Binding Protein 1 Insulin-Like Growth Factor Binding Proteins Gestational diabetes Diabetes Gestational Diabetes Mellitus Type 1 medicine.anatomical_structure biology.protein Female business |
| Zdroj: | Diabetic Medicine. 22:434-439 |
| ISSN: | 1464-5491 0742-3071 |
| DOI: | 10.1111/j.1464-5491.2005.01430.x |
| Popis: | Aims The insulin-like growth factor (IGF) system is considered important in the regulation of fetal growth. Binding of IGFs to specific binding proteins (IGFBPs) modifies their actions. In fetal blood, IGFBP-1 is the primary IGF binding protein whose phosphorylation generates proteins with different affinities for IGF-I. We studied cord serum IGFBP-1 phosphoisoform profiles in normal pregnancies and in diabetic pregnancies, which are frequently complicated by macrosomia. Research design and methods Cord serum IGFBP-1 phosphoisoform concentrations were measured at birth by two immunoenzymometric assays in 67 pregnancies complicated by Type 1 diabetes, in 28 pregnancies complicated by insulin-treated gestational diabetes, and in 62 normal pregnancies. Results Cord serum highly phosphorylated IGFBP-1 (hpIGFBP-1) concentrations were lower in pregnancies complicated by Type 1 diabetes (204 +/- 36 microg/l, P = 0.032) and in pregnancies complicated by gestational diabetes (170 +/- 28 microg/l, P = 0.031) than in controls (316 +/- 34 microg/l). Cord serum lesser phosphorylated IGFBP-1 (lpIGFBP-1) concentrations were similar in diabetic and normal pregnancies (P = 0.692 between groups by analysis of variance). Relative birth weight correlated negatively with cord serum hpIGFBP-1 and lpIGFBP-1 in diabetic pregnancies, and with cord serum lpIGFBP-1 in normal pregnancies. Conclusions Maternal diabetes is associated with suppressed hpIGFBP-1 but unaltered lpIGFBP-1 concentrations in cord serum, suggesting that IGFBP-1 phosphoisoforms are differentially regulated in the fetus. Because hpIGFBP-1 has a higher affinity for IGF-I than does lpIGFBP-1, diabetes-related changes in fetal IGFBP-1 phosphorylation may increase IGF-I bioavailability and, consequently, stimulate fetal growth. This may partly explain the increased occurrence of macrosomia in diabetic pregnancies. |
| Databáze: | OpenAIRE |
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