Obese men have more advanced and more aggressive prostate cancer at time of surgery than non-obese men after adjusting for screening PSA level and age: results from two independent nested case–control studies
| Autor: | Rachel Carlson, Laureano J. Rangel, Richard W. Joseph, Alexander S. Parker, Nancy D. Diehl, Erik J. Bergstralh, David D. Thiel, Robert Jeffrey Karnes |
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| Rok vydání: | 2013 |
| Předmět: |
Male
obesity Cancer Research medicine.medical_specialty Urology MEDLINE urologic and male genital diseases Body Mass Index PSA Prostate cancer Non obese medicine Humans Aged Neoplasm Staging Aged 80 and over business.industry screening Age Factors Case-control study Prostatic Neoplasms aggressiveness Middle Aged Prostate-Specific Antigen medicine.disease Obesity Surgery Prostate-specific antigen Oncology Case-Control Studies Nested case-control study Disease Progression Original Article business Body mass index |
| Zdroj: | Prostate Cancer and Prostatic Diseases |
| ISSN: | 1476-5608 1365-7852 |
| DOI: | 10.1038/pcan.2013.27 |
| Popis: | BACKGROUND: It remains unclear whether the hemodilution effect of body mass index (BMI) on PSA levels translates to inappropriate prostate cancer (PCa) screening in obese men. To address this, we conducted two nested case–control studies within prospective cohorts of men undergoing radical prostatectomy for newly diagnosed PCa. METHODS: We identified 1817 men with BMI ⩾30 kg m−2 (cases) and 1244 men with BMI |
| Databáze: | OpenAIRE |
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