Failed postnatal immunoprophylaxis for hepatitis B: characteristics of maternal hepatitis B virus as risk factors
| Autor: | Siew Lin Ngui, G. S. Underhill, J. Heptonstall, C. G. Teo, N. J. Andrews |
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| Rok vydání: | 1998 |
| Předmět: |
Microbiology (medical)
HBsAg Hepatitis B virus Immunoglobulins Viremia medicine.disease_cause Orthohepadnavirus Pregnancy Risk Factors Medicine Humans Hepatitis B Vaccines Hepatitis B e Antigens Treatment Failure Pregnancy Complications Infectious Retrospective Studies Hepatitis B Surface Antigens biology business.industry Vaccination Immunization Passive Infant Newborn virus diseases Breakthrough infection Hepatitis B biology.organism_classification medicine.disease Virology Infectious Disease Transmission Vertical Infectious Diseases HBeAg Hepadnaviridae Case-Control Studies Immunology DNA Viral Mutation Female business |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 27(1) |
| ISSN: | 1058-4838 |
| Popis: | A retrospective case-control study was conducted to determine why some infants born full-term without obstetric intervention to hepatitis B e antigen (HBeAg)-seropositive mothers become infected by hepatitis B virus (HBV) despite having received passive-active immunoprophylaxis. Cases and controls comprised 12 hepatitis B surface antigen (HBsAg)-seropositive infants and 22 HBsAg-seronegative infants, respectively. Infants infected by putative vaccine-escape mutants were excluded. Risk factors, after adjustment for the level of maternal viremia, were the following allelic base changes in maternal HBV:C158, A328, G365, and A479 (P = .017, .005, .003, and .005, respectively). High-level maternal viremia (i.e., > or = 10(8) genome equivalents/mL) was a significant factor only after adjustment for G365 (P = .027). HBV DNA sequences recovered from one of the cases, the case's mother, and three infected contacts all had the high-risk mutations. Specific allelic mutations in maternal HBV and level of maternal viremia are potential predictors of vertical breakthrough infection. |
| Databáze: | OpenAIRE |
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