Soluble Endoglin Level Increase Occurs Prior to Development of Subclinical Structural Vascular Alterations in Diabetic Adolescents
| Autor: | Cagri Damar, Peyami Cinaz, Nurullah Çelik, Betül Emine Derinkuyu, Esra Doger, Mahmut Orhun Çamurdan, Aysun Bideci, Hamdi Cihan Emeksiz, Mehmet Cuneyt Ozmen, Özge Yüce |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Brachial Artery subclinical atherosclerosis Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Diabetic angiopathy Nitric Oxide Carotid Intima-Media Thickness 03 medical and health sciences 0302 clinical medicine Endocrinology hemic and lymphatic diseases Diabetes mellitus Internal medicine otorhinolaryngologic diseases medicine Albuminuria Humans adolescents Endothelial dysfunction Subclinical infection Analysis of Variance Type 1 diabetes business.industry Endoglin medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 1 Solubility Intima-media thickness Pediatrics Perinatology and Child Health Original Article Female Microalbuminuria Endothelium Vascular medicine.symptom business soluble endoglin type 1 diabetes mellitus Biomarkers Blood Flow Velocity Diabetic Angiopathies Dilatation Pathologic |
| Zdroj: | Journal of Clinical Research in Pediatric Endocrinology |
| ISSN: | 1308-5727 |
| Popis: | Objective: Soluble endoglin (S-endoglin) has been implicated as a potential marker of endothelial dysfunction (ED) and was reported to be elevated in diabetic adults, correlating with the severity of diabetic vasculopathy. However, circulating S-endoglin and its association with other markers of ED have not been formerly analyzed in the first decade of diabetes onset in adolescents with type 1 diabetes mellitus (T1DM). Methods: Fifty-eight adolescents with moderately/poorly controlled T1DM were included in this study and twenty-nine healthy adolescents served as controls. The diabetic group was divided into two groups based on the presence of microalbuminuria, as the microalbuminuria group (n=15) and the normoalbuminuria group (n=43). Functional vascular alterations were evaluated by measuring serum S-endoglin and plasma nitric oxide (NO) concentrations, the flow-mediated dilatation (FMD) of the brachial artery. Carotid intima media thickness (CIMT) was measured for evaluation of structural vascular alterations. Results: The S-endoglin and NO levels of both microalbuminuria and normoalbuminuria groups were higher than those of the control group (for S-endoglin, p=0.047 and p |
| Databáze: | OpenAIRE |
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